PMID: 9530922Apr 8, 1998Paper

Identification of a sex steroid-inducible gene in the neonatal rat hypothalamus

Neuroscience Letters
M SuzukiM Takahashi

Abstract

By the cDNA subtraction between cDNA preparations from androgenized and intact neonate rats hypothalami, granulin/ epithelin (grn) gene was identified as a gene enriched by androgenization. Strong grn mRNA signals were detected by in situ hybridization in the ventromedial nucleus (VMH) and the arcuate nucleus (ARC) of the hypothalamus of a 5-day-old male. The grn gene expression level in the hypothalamus was similar between males and females at birth. At 10 days of age, this level was maintained in males, but decreased to 1/4 in females. Thus, grn can be the gene of which expression in the VMH and ARC is sustained by endogenous androgen in male neonates.

References

Dec 1, 1977·Hormones and Behavior·B S McEwenL C Krey
May 1, 1992·Journal of Neurochemistry·E Bettini, A Maggi
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M ShoyabG D Plowman
Dec 31, 1990·Biochemical and Biophysical Research Communications·A BatemanS Solomon
Mar 20, 1981·Science·N J MacLusky, F Naftolin
Jan 1, 1984·Annual Review of Neuroscience·A P Arnold, R A Gorski

❮ Previous
Next ❯

Citations

Dec 15, 2012·Molecular Neurobiology·Gernot KleinbergerChristine Van Broeckhoven
Nov 19, 2002·Neuroscience Letters·Keisuke YoneharaMasugi Nishihara
Jun 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·A P AugerM M McCarthy
May 20, 2005·Biology of Reproduction·Junwen QinKazuhiko Imakawa
Nov 10, 2005·BMC Genomics·Benoît CadieuxHugh P J Bennett
Oct 29, 2009·BMC Neuroscience·Cara L RyanAndrew Bateman
Sep 7, 2011·Journal of Neuroinflammation·Laila Y Al-Ayadhi, Gehan A Mostafa
Oct 22, 2010·The Journal of Reproduction and Development·Takashi MatsuwakiMasugi Nishihara
Feb 24, 2006·The Journal of Reproduction and Development·Hwi-Cheul LeeMasugi Nishihara
Dec 21, 2006·The Journal of Reproduction and Development·Shuichi ChibaMasugi Nishihara
Jun 25, 2009·The Journal of Reproduction and Development·Shuichi ChibaMasugi Nishihara
Sep 2, 2009·The Journal of Reproduction and Development·Masatoshi SuzukiMasugi Nishihara
Feb 18, 2004·The Journal of Reproduction and Development·Keisuke YoneharaMasugi Nishihara
Dec 10, 2008·Developmental and Comparative Immunology·Patrick C HaningtonMiodrag Belosevic
Oct 2, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Andrew Bateman, Hugh P J Bennett
Apr 8, 2014·Frontiers in Neuroendocrinology·Sara M Schaafsma, Donald W Pfaff
Mar 25, 2008·Protein Science : a Publication of the Protein Society·Dmitri TolkatchevFeng Ni
Oct 24, 2007·Journal of Neurochemistry·Jason L Eriksen, Ian R A Mackenzie
Jun 24, 2004·Brain Research. Brain Research Reviews·Andrea Malaspina, Jacqueline de Belleroche
Jan 13, 2011·The American Journal of Pathology·Fiona PickfordMichael Hutton
Dec 13, 2006·Neurobiology of Aging·Luisa BenussiRoberta Ghidoni
Feb 5, 2002·Molecular Genetics and Metabolism·Masatoshi Suzuki, Masugi Nishiahara
Jul 26, 2014·Bioscience, Biotechnology, and Biochemistry·Kazunori SatoTaku Nedachi
Sep 4, 2007·Behavioural Brain Research·Yuko KayasugaMasugi Nishihara
Jul 22, 2016·The Journal of Reproduction and Development·Mio DokeMasugi Nishihara
Jan 12, 2017·Human Molecular Genetics·Yoshinori TanakaMasugi Nishihara
Dec 20, 2007·Growth Factors·Ricardo R GuerraAndrew Bateman
Jun 17, 2000·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·R DanielA Bateman
May 16, 2006·Journal of the Society for Gynecologic Investigation·Monica Brown JonesNita J Maihle
Jul 31, 2003·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Rachael DanielAndrew Bateman
Jan 14, 2003·Nature Medicine·Zhiheng HeAndrew Bateman
Jul 29, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Colin H P OngAndrew Bateman
Sep 22, 2011·Endocrinology·Hyun-Kyong KimMin-Seon Kim
May 1, 2021·Journal of Neurochemistry·Xiao-Ming WangQing Tian

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.