Identification of a sodium pump Na+ /K+ ATPase α1-targeted peptide for PET imaging of breast cancer

Journal of Controlled Release : Official Journal of the Controlled Release Society
Qian WangMu-Sheng Zeng

Abstract

The sodium pump Na+/K+ ATPase a1 subunit(NKA a1), an attractive cancer-related biomarker and therapeutic target, is closely related to the development and progression of several cancers including breast cancer. Currently, a NKA a1 inhibitor, UNBS1450, has already evidenced its great therapeutic potential in personalized cancer treatment. The ability of non-invasive imaging of NKA a1 expression would be useful for selecting cancer patients who may benefit from this drug. Here, we identified an S3 peptide that is specifically homed to breast cancer by phage display. All data of in vitro and in vivo experiments suggested the excellent targeting character of the S3 peptide. As the binding activity of the S3 phage was positively correlated to the level of NKA α1 expression in various breast cancer cells, NKA α1 was validated as the primary target of the S3 peptide. Based on immunohistochemistry staining result of 107 breast cancer patients, NKA α1 was verified to be a novel tracking marker and a prognostic predictor for breast cancer. Importantly, we proposed and validated an S3 peptide-based radiotracer 18F-ALF-NOTA-S3 for PET (Positron Emission Tomography) imaging of breast cancer and other NKA α1-overexpressing cancers, including...Continue Reading

Citations

Dec 25, 2019·Natural Product Research·Juan QinYao-Lan Li
Dec 25, 2019·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·Fatemeh ArasteMohammad Ramezani
Jun 9, 2020·Biochimica Et Biophysica Acta. Biomembranes·R J ClarkeK Cao
Jun 10, 2021·The Journal of Membrane Biology·Marina Marques ToledoLeandro A Barbosa
Sep 21, 2021·Tissue Barriers·Valerie C AndersonWilliam D Rooney
Oct 9, 2021·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Si TangWei Fan

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