PMID: 8608596Feb 9, 1996Paper

Identification of a Stat gene that functions in Drosophila development

Cell
R YanJ E Darnell

Abstract

A Drosophila Stat gene (D-Stat) with a zygotic segmental expression pattern was identified. This protein becomes phosphorylated on Tyr-704 when coexpressed in Schneider cells with a Drosophila janus kinase (JAK), Hopscotch (HOP). The phosphorylated protein binds specifically to the consensus sequence TTCCCGGAA. Suppressor mutations of hopTum-I, a dominant hyperactive allele of hop whose phenotype is hematocyte overproduction and tumor formation, were selected. One of these mutants, statHJ, mapped to the same chromosomal region (92E) as does D-Stat, had an incompletely penetrant pair rule phenotype, and exhibited aberrant expression of the pair rule gene even skipped (eve) at the cellular blastoderm stage. Two D-STAT-binding sites were identified within the eve stripe 3 enhancer region. Mutations in either of the STAT-binding sites greatly decreased the stripe 3 expression in transgenic flies. Clearly, the JAK-STAT pathway is connected to Drosophila early development.

References

Jan 24, 1992·Cell·D St Johnston, C Nüsslein-Volhard
May 1, 1991·Genes & Development·S SmallM Levine
Nov 11, 1990·Nucleic Acids Research·R Pollock, R Treisman
Apr 30, 1981·Developmental Biology·W P Hanratty, J S Ryerse
Oct 19, 1995·Nature·J N Ihle
Jan 1, 1995·Annual Review of Biochemistry·C Schindler, J E Darnell
Aug 29, 1995·Proceedings of the National Academy of Sciences of the United States of America·D Loncar, S J Singer

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Citations

Feb 1, 1997·Developmental Dynamics : an Official Publication of the American Association of Anatomists·S A DuncanJ E Darnell
Jul 27, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·A C OatesA F Wilks
Dec 18, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·H Luo, C R Dearolf
Sep 1, 1996·Trends in Cell Biology·J BriscoeM Müller
Jun 4, 1999·Progress in Biophysics and Molecular Biology·K Shuai
Feb 13, 2001·Developmental and Comparative Immunology·J B TurpenC Huang
Jul 30, 1999·Developmental and Comparative Immunology·Y Engström
Apr 27, 2000·Molecular Immunology·K Imada, W J Leonard
Jul 20, 1999·Molecular and Cellular Endocrinology·P L BergadS A Berry
Apr 16, 1998·Biochimica Et Biophysica Acta·C R Dearolf
May 18, 1999·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·M S Parker, D D Ourth
Jun 25, 1998·Current Opinion in Immunology·K D LiuM A Goldsmith
Apr 1, 1997·Current Opinion in Cell Biology·C M Horvath, J E Darnell
Oct 31, 1998·Current Opinion in Genetics & Development·T Hoey, U Schindler
Feb 17, 2000·Trends in Cell Biology·M Chatterjee-KishoreG R Stark
May 19, 2000·Cytokine & Growth Factor Reviews·K Takeda, S Akira
Aug 8, 2006·Nature Genetics·Song ShiWillis X Li
Jan 12, 2007·Molecular BioSystems·Cheh Peng Lim, Xinmin Cao
Feb 28, 2003·European Journal of Biochemistry·Shu-Chiun SungChang-Jen Huang
Feb 22, 2008·Proceedings of the National Academy of Sciences of the United States of America·Dmitri Papatsenko, Michael S Levine
Sep 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·Aurel BetzJames E Darnell
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jayme A Souza-NetoGeorge Dimopoulos
Apr 27, 2011·Proceedings of the National Academy of Sciences of the United States of America·Tijana CopfThomas Preat
Jun 11, 1996·Proceedings of the National Academy of Sciences of the United States of America·R YanC R Dearolf
Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·N GhilardiR C Skoda
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·H N CaiM Levine
May 12, 2009·Molecular & Cellular Proteomics : MCP·Maximiliane HilgerMatthias Mann
Jan 5, 1999·The Journal of Experimental Medicine·N KiuchiT Hirano
Dec 19, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·M BehrC Jungwirth
Mar 1, 1997·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·T DeckerA Meinke
Jun 12, 2009·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Gong ChengZhaoxin Zheng
Jul 26, 2013·Molecular Biology of the Cell·Wojciech StecMartin P Zeidler

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