PMID: 12765969May 27, 2003Paper

Identification of a structurally distinct CD101 molecule encoded in the 950-kb Idd10 region of NOD mice

Diabetes
Carlos Penha-GonçalvesL S Wicker

Abstract

Genes affecting autoimmune type 1 diabetes susceptibility in the nonobese diabetic (NOD) mouse (Idd loci) have been mapped using a congenic strain breeding strategy. In the present study, we used a combination of BAC clone contig construction, polymorphism analysis of DNA from congenic strains, and sequence mining of the human orthologous region to generate an integrated map of the Idd10 region on mouse chromosome 3. We found seven genes and one pseudogene in the 950-kb Idd10 region. Although all seven genes in the interval are Idd10 candidates, we suggest the gene encoding the EWI immunoglobulin subfamily member EWI-101 (Cd101) as the most likely Idd10 candidate because of the previously reported immune-associated properties of the human CD101 molecule. Additional support for the candidacy of Cd101 is the presence of 17 exonic single-nucleotide polymorphisms that differ between the NOD and B6 sequences, 10 causing amino acid substitutions in the predicted CD101 protein. Four of these 10 substitutions are nonconservative, 2 of which could potentially alter N-linked glycosylation. Considering our results together with those previous reports that antibodies recognizing human CD101 modulate human T-cell and dendritic cell function...Continue Reading

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Citations

Jun 5, 2013·Database : the Journal of Biological Databases and Curation·Charles A StewardJennifer L Harrow
Jan 1, 2012·The Review of Diabetic Studies : RDS·John P DriverClayton E Mathews
Sep 3, 2003·Diabetes/metabolism Research and Reviews
Nov 1, 2005·Journal of Autoimmunity·Linda S WickerLaurence B Peterson
Oct 18, 2005·Current Opinion in Immunology·Lisa M Maier, Linda S Wicker
Apr 27, 2005·Biochemical and Biophysical Research Communications·Kaori YamajiToshio Ogihara
Jul 16, 2013·Journal of Autoimmunity·Hélène Bour-JordanJeffrey A Bluestone
Jun 8, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Adam L DiamentCraig H Warden
Apr 7, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heather I FraserLinda S Wicker
May 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Daniel B RainbowLinda S Wicker
May 27, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Javid P MohammedJochen Mattner
Oct 7, 2015·The Journal of Immunology : Official Journal of the American Association of Immunologists·Heather I FraserLinda S Wicker
Oct 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Aito UenoYang Yang
Aug 22, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Irina FernandezEdgar Engleman
Mar 28, 2021·International Journal of Medical Microbiology : IJMM·Marius WrageJochen Mattner

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