PMID: 698791Sep 29, 1978Paper

Identification of a subregion within rat neostriatum for the dopaminergic modulation of lateral hypothalamic self-stimulation

Brain Research
D B NeillM S Gold

Abstract

Experiments were conducted to test the hypothesis that the involvement of neostriatal dopaminergic transmission in lateral hypothalamic self-stimulation might be specific to a striatal subregion. Crystalline application of dopamine or D-amphetamine increased self-stimulation rate only when made to ventral anterior striatum (VAS); more dorsal or posterior applications were ineffective. A comparison of dose-response functions for dopamine using solution injections in VAS and posterior striatum (PS) confirmed that only VAS was responsive. Injections or applications of 6-hydroxydopamine suppressed responding only when made into VAS. Haloperidol injections decreased responding only for VAS and not PS injection sites. Applications or injections of scopolamine often increased responding when made into VAS, but this effect was unreliable. Applications or injections of scopolamine to more posterior sites consistently suppressed responding. It was concluded that dopaminergic transmission in VAS, alone among the striatal sites tested, is facilitatory on hypothalamic self-stimulation. The effects of drug applications to nucleus accumbens were generally similar to VAS, and it was suggested that these areas may be functionally similar. An ex...Continue Reading

References

Jan 1, 1976·European Journal of Pharmacology·A J PijnenburgJ M Van Rossum
Jan 1, 1973·Naunyn-Schmiedeberg's Archives of Pharmacology·J M Liebman, L L Butcher
Sep 30, 1971·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·J M Kemp, T P Powell
Apr 23, 1974·Psychopharmacologia·S BoseS N Pradhan
Mar 1, 1974·Journal of Comparative and Physiological Psychology·G Winocur
Apr 1, 1967·Journal of Comparative and Physiological Psychology·I DivacM K Szwarcbart
Mar 1, 1966·Brain : a Journal of Neurology·G RaismanT P Powell
Jun 1, 1966·Journal of Comparative and Physiological Psychology·R UrsinJ Olds
Jun 1, 1961·Journal of Comparative and Physiological Psychology·B L NEWMAN
Dec 1, 1963·Journal of Comparative and Physiological Psychology·R H WURTZ, J OLDS

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Citations

Jan 1, 1983·Psychopharmacology·B G HoebelL Lenard
Jun 1, 1979·Pharmacology, Biochemistry, and Behavior·D M DorsaD De Wied
Mar 1, 1982·Pharmacology, Biochemistry, and Behavior·J E SmithJ D Lane
Oct 1, 1986·Pharmacology, Biochemistry, and Behavior·W H ChurchD B Neill
Dec 21, 2002·Synapse·Roberto A Prado-AlcaláGina L Quirarte

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