Identification of a suitable current waveform for acute stroke imaging

Physiological Measurement
A RomsauerovaD S Holder

Abstract

MFEIT (multi-frequency electrical impedance tomography) has the potential to provide a portable non-invasive neuroimaging method ideal for use in acute stroke. Skin perception has not previously occurred in MFEIT with injected frequencies above 2 kHz, but use in brain imaging requires applied current below 100 Hz, which could stimulate cutaneous nerve endings. The purpose of this work was to find the most suitable current pattern that could be employed in MFEIT measurements in the adult head with the UCLH Mk2.5 system, which applies currents from 20 Hz-1.6 MHz. Single frequency current waveforms of 0.28 mA peak-to-peak at 20 Hz-80 Hz were applied to the forearms of three volunteers; although the skin was abraded, none of these were perceived, which agrees with similar studies in the literature. When a full frequency pattern at 20 Hz-1.6 MHz was applied to the forearm or head in four healthy subjects, with the same current amplitude of 0.28 mA for each component, an unpleasant tingling sensation was perceived, due to summation of the applied currents. The sensation was reduced or abolished by attenuation or removal of frequencies below 100 Hz; the optimal compromise was a pattern with absence of 40 Hz, and with 80 and 20 Hz resp...Continue Reading

References

Mar 10, 2001·Physiological Measurement·A J WilsonB H Brown

❮ Previous
Next ❯

Citations

Jun 29, 2007·Medical & Biological Engineering & Computing·O GiladD S Holder
Sep 2, 2014·Biomedical Engineering Online·Harsh SohalTong In Oh
Aug 1, 2007·Physiological Measurement·A McEwanD S Holder
Aug 1, 2007·Physiological Measurement·Tong In OhDavid Holder
Aug 30, 2012·The Analyst·Richard Bayford, Andrew Tizzard
Jun 6, 2009·Physiological Measurement·L FabriziD S Holder

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.