PMID: 6105618Jul 10, 1980Paper

Identification of a tetrodotoxin-sensitive Na+ channel in a variety in fibroblast lines

Nature
J PouysségurM Lazdunski

Abstract

The action potential Na+ ionophore of excitable cells can be activated either by alkaloid compounds such as veratridine, or by small polypeptide toxins extracted from scorpion venom or sea anemone. One of the main features of this Na+ channel is that it is blocked by tetrodotoxin (TTX). However, we report here that during analysis of Na+ influx in resting fibroblasts, we found that a variety of fibroblast lines also possess a TTX receptor. Veratridine and sea anemone toxin act synergistically to stimulate Na+ influx 7 to 10-fold in hamster and rat fibroblasts. As in excitable cells, this toxin-stimulated Na+ influx is blocked by TTX. Addition of serum to hamster fibroblasts arrested in G0 stimulates Na+ influx three-fold. Observations that TTX does not prevent serum-activated Na+ influx, initiation of DNA synthesis and cell proliferation suggest that the fast Na+ channel which we have identified in fibroblasts is not involved in growth control.

References

May 10, 1979·Nature·K S Koch, H L Leffert
Sep 21, 1979·Biochimica Et Biophysica Acta·G RomeyM Lazdunski
Oct 1, 1974·Physiological Reviews·T Narahashi
Dec 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·W A Catterall, M Nirenberg

❮ Previous
Next ❯

Citations

Jan 1, 1982·Toxicon : Official Journal of the International Society on Toxinology·Y Berwald-NetterN Martin-Moutot
Dec 1, 1995·Brain Research. Molecular Brain Research·J A BlackS G Waxman
Jan 1, 1983·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·A L Kleinhaus, J W Prichard
Feb 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·Y Berwald-NetterF Couraud
Sep 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J F RenaudM Lazdunski
Jul 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·J PouysségurE Van Obberghen-Schilling
May 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·J M Ritchie, H P Rang
Aug 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J PouysségurS Paris
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·M M Walsh-ReitzR W Holley
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P ShragerJ M Ritchie
Mar 29, 1983·Biochemical and Biophysical Research Communications·J C Chambard, J Pouyssegur
Jun 13, 1986·Biochemical and Biophysical Research Communications·T AmédéeM Lazdunski
Jan 1, 1986·Annals of the New York Academy of Sciences·J M Ritchie
Sep 12, 1983·Brain Research·N Martin-MoutotY Berwald-Netter
Aug 14, 1986·Biochemical and Biophysical Research Communications·M J LitzingerM Lazdunski
Sep 23, 1985·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·S BevanJ M Ritchie
Mar 10, 2016·International Journal of Systematic and Evolutionary Microbiology·Ram Hari Dahal, Jaisoo Kim
Dec 3, 2016·International Journal of Systematic and Evolutionary Microbiology·Ram Hari Dahal, Jaisoo Kim
Jan 12, 2017·International Journal of Systematic and Evolutionary Microbiology·Ram Hari Dahal, Jaisoo Kim
Jun 21, 2017·International Journal of Systematic and Evolutionary Microbiology·Ram Hari DahalJaisoo Kim
Nov 1, 1983·The American Journal of Physiology·N Matsuki, K Hermsmeyer
Jul 16, 1982·Biochemical and Biophysical Research Communications·C FrelinM Lazdunski
Apr 21, 1984·Journal of Theoretical Biology·G Matsumoto
Jun 28, 1985·Science·S G Waxman, J M Ritchie

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
R MunsonL Glaser
Proceedings of the National Academy of Sciences of the United States of America
W A Catterall, M Nirenberg
Biochemical and Biophysical Research Communications
C FrelinM Lazdunski
© 2021 Meta ULC. All rights reserved