Identification of a Th2- and Th17-skewed immune phenotype in chronic urticaria with Th22 reduction dependent on autoimmunity and thyroid disease markers

Journal of Cutaneous Pathology
Andrea Primiani MoyRosalynn M Nazarian

Abstract

Chronic urticaria is a condition with many inciting factors and often presents a therapeutic challenge to clinicians. In addition to a central role for mast cells, an immune dysregulated state related to cytokine/chemokine alterations is increasingly being recognized. Biopsies of chronic urticaria (n = 11) and normal skin (n = 5) were evaluated with immunostains for CD117, CD3 and dual stains for CD4/T-bet, GATA-3, STAT-3 or BNC-2 (transcription factors specific and mutually exclusive for Th1, Th2, Th17 and Th22 cells, respectively). Clinical data, including autoantibodies and thyroid function tests, and the number of CD117+ mast cells and percent of Th1, Th2, Th17 and Th22 of CD3+ T-cells were compared. Th2 cells and Th17 cells were significantly more frequent in chronic urticaria than controls. In contrast, there was no significant difference in mast cells, Th1 cells or Th22 cells. Three of nine chronic urticaria patients had evidence of autoimmune disease; biopsies from these patients trended toward a greater number of mast cells and decreased percent of Th-cell subtypes as compared with those without autoimmunity markers, with significantly less Th22 cells. These findings provide novel insight into the role of Th2 and Th17 ...Continue Reading

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Citations

Dec 20, 2016·Laboratory Investigation; a Journal of Technical Methods and Pathology·Andrea P MoyStefan Kraft
Sep 19, 2019·Allergy, Asthma, and Clinical Immunology : Official Journal of the Canadian Society of Allergy and Clinical Immunology·Ciara Jade Bansal, Amolak Singh Bansal
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Feb 20, 2021·Experimental Eye Research·Hazem M MousaVictor L Perez
Apr 4, 2021·Vaccines·Simone GarcovichGiampiero Girolomoni
Mar 23, 2021·Journal of Microbiology and Biotechnology·Xinyue ZhangKun Guo

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