PMID: 6165998Jan 1, 1981Paper

Identification of a third type of lambda light chain in mouse immunoglobulins

Proceedings of the National Academy of Sciences of the United States of America
T AzumaH N Eisen

Abstract

A third type of mouse lambda chain was identified in the course of examining light chains from four myeloma proteins and two monoclonal antibodies. On the basis of their antigenic properties and a characteristic COOH-terminal tryptic peptide, the light chains from these immunoglobulins had previously been provisionally identified as lambda 2 chains. However, four of these chains, designated now as lambda 3 (or lambda III), were found to share constant region features that clearly distinguish them from the other types of mouse lambda chains (lambda 1 and lambda 2). The amino acid sequence of more than 90% of the lambda 3 constant region (from position 120 to the COOH-terminus) was determined. In this region the lambda 3 sequence differs from the lambda 2 constant region at 5 positions and from the lambda 1 constant region at about 30 positions.

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Citations

Nov 1, 1987·Molecular Immunology·D F ZhouG A Gutman
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·B BlombergS Tonegawa
Jun 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·J MillerU Storb
Aug 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·E SelsingU Storb
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·N SakatoT Azuma
Jan 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·B Blomberg, S Tonegawa
Oct 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·T AzumaH N Eisen
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·E B ReillyH N Eisen
Oct 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J LiebermanH N Eisen
Aug 1, 1982·The Journal of Experimental Medicine·A Benammar, P A Cazenave
Aug 1, 1986·Journal of Immunogenetics·D ZhouG A Gutman
Dec 10, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Monika ÁdoriGunilla B Karlsson Hedestam
Apr 14, 1983·Nature·S Tonegawa
Jul 22, 1982·Nature·A L BothwellD Baltimore
May 29, 1998·Immunological Reviews·T Azuma
Aug 1, 1985·European Journal of Immunology·S WeissM R Wabl
Jul 1, 1982·European Journal of Immunology·E B ReillyH N Eisen
May 1, 1987·European Journal of Immunology·R DildropK Rajewsky
Aug 1, 1993·European Journal of Immunology·V V Yurovsky, G Kelsoe
Sep 1, 1983·European Journal of Immunology·Y OnoderaH N Eisen
Apr 1, 1983·European Journal of Immunology·M AmorP A Cazenave
Jun 14, 1996·Science·M CascalhoM Wabl

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