Identification of a third yeast mitochondrial Tom protein with tetratrico peptide repeats

FEBS Letters
U BömerK Dietmeier

Abstract

The mitochondrial outer membrane contains a protein complex with at least eight subunits responsible for recognition and translocation of preproteins synthesized in the cytosol. Two subunits, the receptors Tom20 and Tom70, contain tetratrico peptide repeats that are thought to be involved in protein-protein interactions. We have identified Saccharomyces cerevisiae Tom72, a new Tom protein expressed at a low level. Tom72 is homologous to Tom 70, including seven tetratrico peptide repeats. Tom72 is targeted to the mitochondrial outer membrane, forms a large domain exposed to the cytosol and loosely associates with the translocase complex of the outer membrane. These results suggest that Tom72 represents a ninth, weakly expressed component of the preprotein translocase of the mitochondrial outer membrane.

References

May 1, 1991·Trends in Biochemical Sciences·M Goebl, M Yanagida
Jan 1, 1991·Methods in Enzymology
Dec 1, 1990·The Journal of Cell Biology·H F StegerN Pfanner
Jan 1, 1990·Methods in Enzymology·J Hein
Jul 1, 1995·Trends in Biochemical Sciences·J R LambP Hieter
Mar 1, 1995·Trends in Biochemical Sciences·T LithgowG Schatz
Oct 1, 1994·Yeast·A Horvath, H Riezman
Oct 1, 1993·The Journal of Cell Biology·B D GambillN Pfanner
Jan 1, 1995·Methods in Enzymology·A AlconadaN Pfanner
Feb 1, 1996·Trends in Biochemical Sciences·N PfannerG C Shore

❮ Previous
Next ❯

Citations

Mar 27, 2002·Archives of Biochemistry and Biophysics·Abhijit MukhopadhyayHenry Weiner
Nov 5, 1999·Biochimica Et Biophysica Acta·W VoosN Pfanner
Feb 8, 2000·The International Journal of Biochemistry & Cell Biology·M T RyanN Pfanner
Sep 21, 2000·The Plant Journal : for Cell and Molecular Biology·M GutensohnU I Flügge
Nov 5, 1997·DNA and Cell Biology·S D NuttallN J Hoogenraad
Jun 17, 2003·Molecular Biology of the Cell·Hiromi SesakiRobert E Jensen
Sep 9, 2010·Acta Crystallographica. Section F, Structural Biology and Crystallization Communications·Jingzhi LiBingdong Sha
Jan 1, 1997·Annual Review of Biochemistry·W Neupert
Jan 1, 1997·Annual Review of Cell and Developmental Biology·N PfannerA Hönlinger
Aug 10, 2011·The Journal of Cell Biology·Drazen PapicDoron Rapaport
Aug 31, 2002·Cell Communication & Adhesion·Angela M EdmonsonGeorge Argyropoulos
Jun 12, 2012·Biochimica Et Biophysica Acta·Jan DudekMartin van der Laan
Jul 27, 2010·Biochimica Et Biophysica Acta·Toshiya EndoShin Kawano
Aug 23, 2002·Biochimica Et Biophysica Acta·Toshiya Endo, Daisuke Kohda
Dec 1, 2009·Biochimica Et Biophysica Acta·Toshiya Endo, Koji Yamano
Sep 13, 2019·Biological Chemistry·Alexander GrevelThomas Becker
Oct 7, 2020·International Journal of Molecular Sciences·Sebastian Kreimendahl, Joachim Rassow
Mar 1, 1997·Trends in Cell Biology·V Haucke, G Schatz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antibody Specificity

Antibodies produced by B cells are highly specific for antigen as a result of random gene recombination and somatic hypermutation and affinity maturation. As the main effector of the humoral immune system, antibodies can neutralize foreign cells. Find the latest research on antibody specificity here.