Identification of a Toll-like receptor 1 in guinea fowl (Agelastes niger)

Biochemical Genetics
Yanhua WuHuanrong Li

Abstract

Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns, thus playing important roles in host defense. This study determined the first sequence of a TLR1 type 1 in the guinea fowl (GFTLR1). The open reading frame of GFTLR1 type 1 contains 2,115 nucleotides and encodes 705 amino acids. Amino acid analysis indicated that GFTLR1 type 1 shares 92.3 % homology with the green jungle fowl, 92.1 % with the chicken, 90.4 % with the turkey, and 84.4 % with Cooper's hawk. Genetic patterns were identified within the TLR1 type 1 of the chicken and the guinea fowl. GFTLR1 type 1 was found to have 92 polymorphic amino acid sites, of which 16 were in the leucine-rich repeat (LRR) domain, 3 in a C-terminal LRR domain, and 6 in a Toll/interleukin-1 receptor domain. The data showed that avian TLR1 type 1 genes are under purifying selection and highly conserved, because dN/dS was less than 1.

References

Feb 1, 1997·Current Opinion in Immunology·R Medzhitov, C A Janeway
Mar 22, 2002·Nature Reviews. Immunology·R Medzhitov
Mar 26, 2002·Nature Immunology·Adeline M HajjarSamuel I Miller
Dec 7, 2002·Current Topics in Microbiology and Immunology·B Beutler, M Rehli
Aug 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Stephen N WhiteJames E Womack
Dec 4, 2004·Immunogenetics·Ahmet YilmazJames J Zhu
Jun 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Jared C RoachAlan Aderem
Nov 9, 2005·Molecular Phylogenetics and Evolution·Yi-Ping LiuYa-Ping Zhang
Feb 25, 2006·Cell·Shizuo AkiraOsamu Takeuchi
Mar 23, 2006·Annual Review of Immunology·Bruce BeutlerKasper Hoebe
May 10, 2007·Molecular Biology and Evolution·Koichiro TamuraSudhir Kumar
Jun 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Christopher M JohnsonRichard I Tapping
Jun 28, 2007·European Journal of Immunology·Thomas R HawnAlan Aderem
Jan 31, 2008·Clinical Science·E Ann Misch, Thomas R Hawn
Apr 15, 2008·Cellular and Molecular Life Sciences : CMLS·J BellaS C Lovell
Jul 9, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Catherine WalshClare Bryant
Jul 19, 2008·American Journal of Respiratory and Critical Care Medicine·Mark M WurfelThomas R Martin
Aug 15, 2008·Immunity·Mi Sun Jin, Jie-Oh Lee
Sep 24, 2008·Immunogenetics·Toshiaki NakajimaAkinori Kimura
Oct 22, 2008·BMC Evolutionary Biology·Oliver C JannElizabeth J Glass
Jan 31, 2009·Molecular Biology and Evolution·Gabriela WlasiukMichael W Nachman
Feb 13, 2009·Trends in Immunology·Dirk WerlingTracey J Coffey
Jun 11, 2009·The Journal of Biological Chemistry·Kamalpreet NagpalDouglas T Golenbock
Apr 23, 2010·Molecular Biology and Evolution·Gabriela Wlasiuk, Michael W Nachman
Jan 18, 2011·Molecular Biology and Evolution·Miguel Alcaide, Scott V Edwards
Jul 1, 2011·Molecular Biology Reports·Wenke RuanShijun J Zheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.