Identification of a ToxR-activated gene, tagE, that lies within the accessory colonization factor gene cluster of Vibrio cholerae O395

Gene
M E KovachK M Peterson

Abstract

The nucleotide (nt) sequence has been determined for a Vibrio cholerae ToxR-activated gene designated tagE that is located within a cluster of genes required for efficient intestinal colonization. The tagE gene encompasses 909 nt and is predicted to encode a 303-amino-acid (aa) protein with an estimated molecular mass of 34,468 Da. Computer-assisted similarity searches revealed that TagE possesses aa sequence similarity with Escherichia coli OrfU and Staphylococcus simulans lysostaphin, two proteins that are involved in cell-wall biosynthesis and peptidoglycan degradation, respectively. The role, if any, that TagE plays in the accessory colonization factor phenotype is currently under investigation.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·F SangerA R Coulson
Feb 1, 1992·Molecular Microbiology·V J DiRita
Jun 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·V J DiRitaJ J Mekalanos
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
May 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·R K TaylorJ J Mekalanos
Feb 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·S Tabor, C C Richardson
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·P A RecseiR P Novick
Jun 11, 1986·Nucleic Acids Research·G von Heijne
Apr 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·J Shine, L Dalgarno
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·V L Miller, J J Mekalanos

❮ Previous
Next ❯

Citations

Apr 10, 2002·Microbiology and Immunology·Shah M Faruque, G Balakrish Nair
Feb 17, 2001·Infection and Immunity·D K KaraolisP R Reeves
May 25, 2004·Infection and Immunity·Jyoti Mathur, Matthew K Waldor
Sep 20, 2007·The Journal of General and Applied Microbiology·Chariya ChomvarinChulapan Engchanil
Mar 14, 1997·Journal of Molecular Biology·D MazelP Marlière
Nov 5, 2015·Molecular Plant Pathology·Jeffrey J Coleman
Dec 9, 2004·DNA and Cell Biology·Shah M FaruqueJohn J Mekalanos
Dec 5, 1998·Microbiology and Molecular Biology Reviews : MMBR·S M FaruqueJ J Mekalanos
Sep 8, 1999·Microbiology and Molecular Biology Reviews : MMBR·A MaraisF Mégraud

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.