Identification of a unique apolipoprotein E allele in Microcebus murinus; ApoE brain distribution and co-localization with beta-amyloid and tau proteins

Neurobiology of Disease
A CalendaN Bons

Abstract

This report is devoted to the characterization of the apolipoprotein E (ApoE) in Microcebus murinus. Only one allele homologous to the human ApoE4 allele was evidenced. The distribution of the corresponding ApoE protein in the brain was found in association with the pathological proteins characteristic of Alzheimer's disease (AD). Immunocytochemistry revealed brain deposits of ApoE in: (1) the cortical amyloid plaques; (2) the neurones of the various cortical lobes, the hippocampus and the brainstem; (3) the glial cells, astrocytes of the cortical parenchym and oligodendrocytes of the corpus callosum; and (4) the vessel walls. Most ApoE, beta-amyloid protein, abnormally phosphorylated Tau proteins and gliofilament acid proteins were seen in the same cortical areas. These findings for ApoE report the view that Microcebus murinus, in captivity, presents a pathological profile very similar to that observed in AD.

Citations

Apr 20, 2007·Journal of Neurochemistry·Debora DumontJohan Robben
Feb 28, 2016·Biological Research·Claudia SalazarAdrián G Palacios
Feb 24, 2001·Annals of the New York Academy of Sciences·R M Sapolsky, C E Finch
Nov 25, 1997·Brain Research. Brain Research Reviews·L C Walker
Dec 22, 1999·Neurobiology of Aging·C E Finch, R M Sapolsky

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