Identification of a yeast artificial chromosome spanning the 8q12 translocation breakpoint in pleomorphic adenomas with t(3;8)(p21;q12)

Genes, Chromosomes & Cancer
E RöijerG Stenman

Abstract

A subgroup of pleomorphic adenomas of the salivary glands is characterized by translocations involving chromosome 8, with consistent breakpoints at 8q12. As part of a positional cloning effort to isolate the gene(s) affected by these translocations we now report the mapping of the 8q12 breakpoint in two primary pleomorphic adenomas with the recurrent t(3;8)(p21;q12). Yeast artificial chromosome (YAC) clones corresponding to eight different loci in 8q11-12 were isolated and mapped by fluorescence in situ hybridization (FISH). The t(3;8) breakpoint was mapped within a 1 Mb region flanked by MOS proximally and by the genetic marker D8S166 distally. One YAC within this region was shown to span the t(3;8) breakpoint in two tumors. This YAC will provide an excellent tool for isolating the gene(s) at the breakpoint(s) in adenomas with t(3;8).

References

Aug 1, 1992·Cancer Genetics and Cytogenetics·Y OhjimiM Kikuchi
Feb 1, 1990·Cancer Genetics and Cytogenetics·J SandrosJ Mark
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·H M AlbertsenD Cohen
May 1, 1986·Cancer Genetics and Cytogenetics·A A SandbergC K Tebbi
Jun 1, 1994·Genes, Chromosomes & Cancer·A NordkvistG Stenman
Jun 1, 1994·Nature Genetics·G GyapayJ Weissenbach
Jan 1, 1995·Cytogenetics and Cell Genetics·S WoodM L Yaremko
Aug 1, 1994·Cancer Genetics and Cytogenetics·J R SawyerJ M Bell
May 1, 1994·Genomics·M SapruM Wagner

❮ Previous
Next ❯

Citations

Mar 21, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·E RöijerG Stenman
Jul 19, 2005·Laboratory Investigation; a Journal of Technical Methods and Pathology·Sue RutherfordChristopher A Moskaluk
Feb 13, 2002·The American Journal of Pathology·Eva RöijerGöran Stenman

❮ Previous
Next ❯

Related Concepts

Related Feeds

Artificial Chromosomes

Artificial chromosomes are genetically engineered chromosomes derived from the DNA of a species. Discover the latest research on artificial chromosomes here.

Related Papers

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
F CarinciA Pastore
© 2021 Meta ULC. All rights reserved