Identification of aberrantly expressed miRNAs in rectal cancer

Oncology Reports
Xinhua LiWei Wu

Abstract

Disturbance of miRNA expression may play a key role in the initiation and progression of colorectal cancer (CRC). CRC should be viewed as a heterogeneous disease, but previous studies have only screened dysregulated miRNAs in CRC from a panel of 96, 145, 287 and 455 miRNAs, respectively. It is necessary to identify new aberrantly expressed miRNAs in rectal cancer. In this study tissue samples were derived from patients undergoing a surgical procedure to remove a portion of cancers. The expression profile of 904 miRNAs was analyzed using a miRCURY™ LNA Array from 6-paired rectal cancers and normal tissues. The expression levels of 4 miRNAs were compared by real-time PCR between colon and rectal cancer, and also the expression levels of metastatic miRNAs in different stages of rectal cancer were analyzed. We found that 67 miRNA precursors are upregulated in rectal cancer (p<0.05) and 21 of those have never been reported in colorectal cancer (CRC); 39 miRNA precursors are downregulated (p<0.05) and 24 novel dysregulated miRNAs were identified in rectal cancer. miR-31, miR-126 and miR-143 are differentially expressed between colon cancer and rectal cancer. Here, we report an miRNA profile of rectal cancer, and we identified differe...Continue Reading

Citations

Dec 26, 2013·Experimental and Molecular Pathology·Faeza EbrahimiAlfred King-Yin Lam
Feb 13, 2016·Genes, Chromosomes & Cancer·Raphael PelossofJulio Garcia-Aguilar
Oct 4, 2015·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Lory SantarelliMarco Tomasetti
Oct 13, 2015·Experimental Cell Research·Faeza EbrahimiAlfred King-Yin Lam
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Jul 30, 2020·Cancers·Laura ImedioJesús García-Foncillas

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