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Identification of Adenosine-to-Inosine RNA Editing with Acrylonitrile Reagents

Organic Letters

Oct 4, 2019

Ying LiRobert C. Spitale

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Abstract

New chemical probes have been designed to facilitate the identification of adenosine-to-inosine (A-to-I) edited RNAs. These reagents combine a conjugate acceptor for selective inosine covalent modification with functional groups for bioorthogonal biotinylation. The resulting biotinylate...read more

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Acrylonitrile
Adenosine
Inosine
RNA
Site
Protein Biotinylation
Quantitative Reverse Transcriptase PCR
Chemical Probe
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Identification of Adenosine-to-Inosine RNA Editing with Acrylonitrile Reagents

Organic Letters

Oct 4, 2019

Ying LiRobert C. Spitale

PMID: 31516001

DOI: 10.1021/acs.lett.9b02929

Abstract

New chemical probes have been designed to facilitate the identification of adenosine-to-inosine (A-to-I) edited RNAs. These reagents combine a conjugate acceptor for selective inosine covalent modification with functional groups for bioorthogonal biotinylation. The resulting biotinylate...read more

Mentioned in this Paper

Acrylonitrile
Adenosine
Inosine
RNA
Site
Paper Details
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