Identification of adjuvants that enhance the therapeutic antibody response to host IgE

Vaccine
Jeannette JohanssonL Hellman

Abstract

In the development of a novel vaccine against atopic allergies, we have screened for adjuvants that enhance the therapeutic antibody response against self immunoglobulin E (IgE). The response against self IgE is induced by administration of a vaccine antigen, which contains both self and non-self IgE regions, together with an adjuvant. We evaluated five commonly used adjuvants; Freund's, aluminium hydroxide, ISCOMs, Montanide ISA 51 and Montanide ISA 720, and found that the mineral oil-based adjuvants; Montanide ISA 51 and Freund's induced at least 5-10-fold higher anti-self IgE titers than any of the other candidates. However, with one exception, Alum, the immune responses against the carrier, i.e. the non-self regions, were similar for all adjuvants, indicating that the ability to induce responses against self and non-self antigens differ among adjuvants. The responses against non-self IgE were more than 50-fold higher than antibody responses against self IgE in both the Freund's and Montanide 51-administered animals, indicating that the response against self molecules is markedly inhibited by tolerance-inducing mechanisms. Co-administration of Montanide ISA 51 with immuno-stimulatory substances from bacteria; muramyldipeptid...Continue Reading

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Citations

Jul 20, 2010·Immunotherapy·Alexander Link, Martin F Bachmann
Mar 8, 2008·Expert Review of Vaccines·Lars Hellman
Aug 16, 2008·Journal of Pharmaceutical Sciences·Jennifer H Wilson-WelderBalaji Narasimhan
Jul 30, 2008·International Journal of Pharmaceutics·Surya K Mallapragada, Balaji Narasimhan
Nov 13, 2007·Veterinary Immunology and Immunopathology·Lidija HabjanecJelka Tomasić
Dec 6, 2006·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lars Hellman
Oct 29, 2014·Angiogenesis·Xiaodong ZhuangRoy Bicknell
Dec 21, 2016·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Falk SaupeAnna-Karin Olsson
Jan 10, 2018·Frontiers in Immunology·Lars Torkel HellmanZhirong Fu

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