PMID: 2118019Jan 1, 1990Paper

Identification of ADPR-transferase activity in the rat tapeworm, Hymenolepis diminuta

Comparative Biochemistry and Physiology. B, Comparative Biochemistry
M AlsharifR V Brunt

Abstract

1. The nuclear fraction of the rat tapeworm Hymenolepis diminuta (Cestoda) contains the enzyme adenosine diphosphoribosyl transferase (ADPR-transferase). 2. The enzyme catalyzes the postsynthetic modification of some nuclear proteins by the covalent attachment of the (ADP-ribose) moiety of NAD to such proteins. 3. The reaction is dependent on DNA which contains strand-breaks, and chain lengths equivalent to (ADP-ribose) is estimated. 4. The formation of polynucleotide products was competitively inhibited by 3-acetamidobezamide, with a Km of 125 microM. 5. The catalytic properties of ADPR-transferase in Hymenolepis diminuta are similar to those in T. brucei.

References

Mar 1, 1985·Molecular and Biochemical Parasitology·F FarzanehP Borst
Dec 1, 1985·Biochemical Pharmacology·A W CornelissenS Shall
Jan 1, 1985·Zeitschrift Für Parasitenkunde·C J Brandford White, J B Hipkiss
Sep 2, 1985·FEBS Letters·U Wintersberger, E Wintersberger
Jan 1, 1985·Zeitschrift Für Parasitenkunde·J B Hipkiss, C J Branford White
Feb 7, 1980·Nature·B W DurkaczS Shall
Mar 1, 1980·The Biochemical Journal·M R Purnell, W J Whish
Mar 18, 1982·Nature·D Creissen, S Shall
Mar 1, 1983·The Biochemical Journal·E E Okolie, N I Onyezili
Jul 1, 1980·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K IkaiO Hayaishi

❮ Previous
Next ❯

Citations

Apr 1, 1993·International Journal for Parasitology·J Walker, J Barrett
Apr 1, 1993·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S KappusW J Whish

❮ Previous
Next ❯

Related Concepts

Related Feeds

African Trypanosomiasis

African trypanosomiasis, also known as sleeping sickness, is an insect-borne parasitic disease of humans and other animals. It is caused by protozoa of the species Trypanosoma brucei and almost invariably progresses to death unless treated. Discover the latest research on African trypanosomiasis here.