Identification of Adult Mesodermal Progenitor Cells and Hierarchy in Atherosclerotic Vascular Calcification

Stem Cells
Hyun-Jai ChoHyo-Soo Kim

Abstract

The nature of calcifying progenitor cells remains elusive. In this study, we investigated the developmental hierarchy and dynamics of progenitor cells. In vitro and in vivo reconstitution assays demonstrated that Sca-1+/PDGFRα- cells in the bone marrow (BM) are the ancestors of Sca-1+/PDGFRα+ cells. Cells of CD29 + Sca-1+/PDGFRα- lineage in the BM showed both hematopoietic potential with osteoclastic differentiation ability as well as mesenchymal stem cell-like properties with osteoblastic differentiation potential. Clonally-isolated BM-derived artery-infiltrated Sca-1+/PDGFRα- cells maintained osteoblastic/osteoclastic bipotency but lost hematopoietic activity. In hypercholesterolemic apolipoprotein-E-deficient (Apoe-/-) mice, the mobilization from BM to peripheral circulation, followed by migration into atherosclerotic plaques of Sca-1+/PDGFRα- cells, but not Sca-1+/PDGFRα+ cells, were significantly decreased, and Interleukin-1β (IL-1β) and Interleukin-5 (IL-5) mediated this response. Here, we demonstrated that Sca-1+/PDGFRα- cells are mesodermal progenitor cells in adults, and the dynamics of progenitor cells were regulated by atherosclerosis-related humoral factors. These results may contribute to better understanding of va...Continue Reading

References

Jul 1, 1988·Science·G J SpangrudeI L Weissman
Jul 31, 1999·Experimental Hematology·G D Roodman
Sep 16, 2000·Experimental Hematology·R J Deans, A B Moseley
Apr 8, 2003·Journal of Cell Science·Naoki NakayamaChun-Ya E Han
Aug 5, 2003·Journal of Cellular Biochemistry·Melody BaddooDonald G Phinney
Oct 29, 2003·Circulation·Yin TintutLinda L Demer
May 13, 2005·The New England Journal of Medicine·Guiti Z Eghbali-FatourechiSundeep Khosla
Nov 3, 2005·Nature Clinical Practice. Cardiovascular Medicine·Per Bergman, Jan van der Linden
Feb 27, 2007·Bone·Guiti Z Eghbali-FatourechiSundeep Khosla
May 17, 2008·Genes & Development·Johanna AndraeChrister Betsholtz
Jul 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jenna N PassmanMark W Majesky
Oct 22, 2008·Journal of the American College of Cardiology·Mario GösslSundeep Khosla
Nov 11, 2008·Stem Cells and Development·Mario PetriniNader G Abraham
Mar 24, 2009·Annual Review of Immunology·Elena Galkina, Klaus Ley
Jul 29, 2010·Nature Reviews. Cardiology·Andrew P SageLinda L Demer
Dec 24, 2010·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Jacob AndradeGay M Crooks
Jun 6, 2012·Circulation·Gian Paolo FadiniSundeep Khosla
Jun 19, 2012·Cell Stem Cell·Armand Keating
Aug 21, 2012·Trends in Endocrinology and Metabolism : TEM·K MarinouM Koutsilieris
Jan 8, 2013·Trends in Cardiovascular Medicine·Jesper HjortnaesElena Aikawa
Mar 26, 2014·Arteriosclerosis, Thrombosis, and Vascular Biology·Linda L Demer, Yin Tintut
Dec 4, 2014·Cell Stem Cell·Rafael KramannBenjamin D Humphreys
Apr 4, 2015·Nature Communications·Michael CohenJames Briscoe

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Citations

Apr 8, 2020·International Journal of Molecular Sciences·Yi-Chou HouKuo-Cheng Lu
May 11, 2021·Frontiers in Cardiovascular Medicine·Wenhong JiangXiao Qin

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