Identification of age- and disease-related alterations in circulating miRNAs in a mouse model of Alzheimer's disease

Frontiers in Cellular Neuroscience
Sylvia Garza-ManeroAngélica Zepeda

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder characterized clinically by the progressive decline of memory and cognition. Histopathologically, two main hallmarks have been identified in AD: amyloid-β peptide extracellular neuritic plaques and neurofibrillary tangles formed by posttranslational modified tau protein. A definitive diagnosis can only be achieved after the post mortem verification of the histological mentioned alterations. Therefore, the development of biomarkers that allow an early diagnosis and/or predict disease progression is imperative. The prospect of a blood-based biomarker is possible with the finding of circulating microRNAs (miRNAs), a class of small non-coding RNAs of 22-25 nucleotides length that regulate mRNA translation rate. miRNAs travel through blood and recent studies performed in potential AD cases suggest the possibility of finding pathology-associated differences in circulating miRNA levels that may serve to assist in early diagnosis of the disease. However, these studies analyzed samples at a single time-point, limiting the use of miRNAs as biomarkers in AD progression. In this study we evaluated miRNA levels in plasma samples at different time-points of the evolution of an AD-like ...Continue Reading

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Citations

Aug 10, 2016·Biomolecular Concepts·Manasa Basavaraju, Alexandre de Lencastre
Jul 18, 2020·International Journal of Molecular Sciences·Alex Cleber Improta-CariaBruno Solano de Freitas Souza
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Dec 16, 2019·Neurochemistry International·Mario J BertogliatRaghu Vemuganti
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Methods Mentioned

BETA
transgenic
PCR
GTPases

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