Jan 24, 2014

Identification of age-related macular degeneration related genes by applying shortest path algorithm in protein-protein interaction network

BioMed Research International
Jian ZhangLei Chen


This study attempted to find novel age-related macular degeneration (AMD) related genes based on 36 known AMD genes. The well-known shortest path algorithm, Dijkstra's algorithm, was applied to find the shortest path connecting each pair of known AMD related genes in protein-protein interaction (PPI) network. The genes occurring in any shortest path were considered as candidate AMD related genes. As a result, 125 novel AMD genes were predicted. The further analysis based on betweenness and permutation test indicates that there are 10 genes involved in the formation or development of AMD and may be the actual AMD related genes with high probability. We hope that this contribution would promote the study of age-related macular degeneration and discovery of novel effective treatments.

Mentioned in this Paper

Laboratory Procedures
Protein-Protein Interaction
Nonexudative Age-related Macular Degeneration
Protein Interaction Maps
Genetic Predisposition to Disease
Computational Molecular Biology
Age Related Macular Degeneration

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