Identification of allelic variants of the bovine immune regulatory molecule CEACAM1 implies a pathogen-driven evolution

Gene
Robert KammererWolfgang Zimmermann

Abstract

Carcinoembryonic antigen-related cell adhesion molecule (CEACAM1), the primordial member of the carcinoembryonic antigen (CEA) family, functions as a MHC-independent natural killer (NK) cell inhibitory receptor, regulates T and B cell proliferation, and induces dendritic cell (DC) maturation. Despite these fundamental functions, CEACAM1 and most of the CEA family members differ significantly in primates and rodents. A number of diverse murine and human pathogens use CEACAM1 as a cellular receptor, indicating that the observed species-specific differences are the result of divergent molecular pathogen/host coevolution. To gain deeper insight into its evolution and function, we cloned CEACAM1 cDNA from cattle as a representative of a third mammalian order. Bovine CEACAM1 differs considerably from rodent and primate CEACAM1 due to deletion of the B domain exon which was most likely caused by insertion of LINE/SINE sequences and reveals alternative splicing within the transmembrane exon. However, the characteristic long and short isoforms exist which contain or lack the typical immunoreceptor tyrosine-based inhibitory motifs (ITIM) in their cytoplasmic tails, respectively. Bovine peripheral blood lymphocytes (PBL) express only ITIM...Continue Reading

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Citations

Oct 24, 2012·The Journal of Biological Chemistry·Guiqing PengFang Li
Nov 1, 2011·American Journal of Physiology. Lung Cellular and Molecular Physiology·Cheryl ChapinPhilip L Ballard
Mar 31, 2009·American Journal of Physiology. Lung Cellular and Molecular Physiology·Venkatadri KollaPhilip L Ballard
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Jun 10, 2016·Reproduction : the Official Journal of the Society for the Study of Fertility·Denis AleksicRobert Kammerer
Mar 24, 2016·International Reviews of Immunology·Ilan VolovitzAttila Tárnok
Dec 31, 2016·The Journal of Biological Chemistry·Guiqing PengFang Li
Mar 17, 2018·BMC Evolutionary Biology·Sophie MißbachRobert Kammerer
May 1, 2018·Journal of Dairy Science·Andrew MareteDidier Boichard

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