Identification of altered microRNAs in serum of a mouse model of Parkinson's disease

Neuroscience Letters
Hector Rosas-HernandezSumit Sarkar

Abstract

Parkinson's disease (PD) is the second most prevalent neurodegenerative disease, whose hallmark is the loss of dopamine terminals in the substantia nigra pars compacta (SNpc). PD is usually diagnosed after the appearance of motor symptoms, when about 70% of neurons in the SNpc have already been lost. Because of that, it is important to search for new methods that aid in the early diagnosis of PD. In recent years, microRNAs (miRs) have emerged as potential biomarkers for a variety of diseases and hold the potential to be used to aid in the diagnosis of PD. Therefore, the aim of this study was to characterize if specific miRs are differentially expressed in serum in a mouse model of PD. To induce PD-like damage, mice were subcutaneously injected with 25 mg/kg of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride (MPTP) by administering 10 doses over a period of 5 weeks, with 3.5 days between doses. Expression of 71 different microRNAs was quantified in serum separated from blood collected at day 35, using next-generation sequencing. Histological analysis and quantification of neurotransmitters were performed to confirm dopaminergic neurodegeneration. Chronic MPTP treatment induced loss of dopaminergic terminals in the SNp...Continue Reading

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Citations

Nov 14, 2019·International Journal of Molecular Sciences·Suh Yee GohSamuel Sam-Wah Tay
Feb 6, 2019·Journal of Experimental & Clinical Cancer Research : CR·Lu ZhangLiling Tang
Apr 17, 2021·Frontiers in Genetics·Saltanat KamenovaAnatoliy Ivashchenko
Apr 23, 2021·Cellular and Molecular Neurobiology·Jinying XuGuangfan Chi
Nov 26, 2021·Radiology and Oncology·Andrej RenceljMaja Cemazar

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