Identification of ambient fine particulate matter components related to vascular dysfunction by analyzing spatiotemporal variations

The Science of the Total Environment
Chia-Chi HoPinpin Lin

Abstract

Exposure to ambient fine particulate matter (PM2.5) has been associated with vascular diseases in epidemiological studies. We have demonstrated previously that exposure to ambient PM2.5 caused pulmonary vascular remodeling in mice and increased vascular smooth muscle cells (VSMCs) viability. Here, we further demonstrated that exposure of mice to ambient PM2.5 increased urinary 8‑hydroxy‑2'‑deoxyguanosine (8-OHdG) and cytokines concentrations in the broncheoalveolar lavage. The objective of the present study was to identify the PM2.5 components related to vascular dysfunction. Exposure to PM2.5 collected from various areas and seasons in Taiwan significantly increased viability, oxidative stress, and inflammatory cytokines secretion in VSMCs. The mass concentrations of benz[a]anthracene (BaA), benzo[e]pyrene (BeP), perylene, dibenzo[a,e]pyrene, molybdenum, zinc (Zn), vanadium (V), and nickel in the PM2.5 were significantly associated with increased viability of VSMCs. These components, except BaA and BeP, also were significantly associated with chemokine (CC motif) ligand 5 (CCL5) concentrations in the VSMCs. The effects of V and Zn on cell viability and CCL5 expression, respectively, were verified. In addition, the mass concent...Continue Reading

Citations

Apr 23, 2021·Cardiovascular Toxicology·Noor Ul Ain, Safi Ur Rehman Qamar
Jul 10, 2021·Environmental Science and Pollution Research International·Marimuthu Rajendran EzhilkumarPrashant Hegde
Jun 26, 2020·Ecotoxicology and Environmental Safety·Zhaohui XueXiaohong Kou

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