Identification of an Adrenomedullin precursor fragment in plasma of sepsis patients

Peptides
Joachim StruckA Bergmann

Abstract

Adrenomedullin and PAMP are potent vasodilatory peptides derived from a common larger precursor peptide. Elevation of circulating levels of both peptides has been described for diseases involving dysfunction of the cardiovascular system. However, the reliable quantification has been hampered by their short half-life times and - as known for Adrenomedullin -- the existence of a binding protein. Here we report the identification of another peptide derived from the Adrenomedullin precursor, termed proADM 45-92, which is present in large concentrations in plasma of septic shock patients. This peptide is produced in stoichiometric amounts to Adrenomedullin and PAMP, but -- contrary to them -- is apparently non-functional and stable. Thus, proADM 45-92 represents a suitable diagnostic target which could be used to assess the concentrations of Adrenomedullin gene products released into the bloodstream.

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Citations

Jun 27, 2012·Current Heart Failure Reports·Mihael PotockiChristian Mueller
Sep 1, 2007·Current Opinion in Critical Care·Philipp SchuetzBeat Müller
Oct 5, 2012·Clinical Microbiology Reviews·Konrad ReinhartChristiane S Hartog
Dec 17, 2005·Critical Care : the Official Journal of the Critical Care Forum·Mirjam Christ-CrainBeat Müller
Jun 30, 2006·Critical Care : the Official Journal of the Critical Care Forum·Mirjam Christ-CrainBeat Müller
Jun 10, 2010·Critical Care : the Official Journal of the Critical Care Forum·Philipp SchuetzUNKNOWN ProHOSP Study Group
Dec 14, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Michael BehnesMartina Brueckmann
Jul 30, 2011·Future Cardiology·Jonathan W Waks, Benjamin M Scirica
Feb 19, 2014·Critical Care : the Official Journal of the Critical Care Forum·Rossella MarinoSalvatore Di Somma
Oct 29, 2014·Current Infectious Disease Reports·Todd A Florin, Lilliam Ambroggio
Sep 5, 2012·Expert Review of Clinical Pharmacology·Juan F FernandezMarcos I Restrepo
Oct 1, 2008·Expert Review of Respiratory Medicine·Mirjam Christ-CrainBeat Müller
Dec 18, 2007·Endothelium : Journal of Endothelial Cell Research·Philipp SchuetzBeat Müller
Nov 11, 2011·Amyloid : the International Journal of Experimental and Clinical Investigation : the Official Journal of the International Society of Amyloidosis·Giovanni PalladiniGiampaolo Merlini
Dec 27, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yosuke SuzukiHiroki Itoh
May 1, 2012·Pathologie-biologie·M Adib-Conquy, J-M Cavaillon
Mar 20, 2012·Trends in Endocrinology and Metabolism : TEM·Patricia M Lenhart, Kathleen M Caron
Mar 29, 2011·Critical Care Clinics·Corey E Ventetuolo, Mitchell M Levy
Oct 19, 2010·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Meta MichelsAndré J A M van der Ven
Jul 19, 2013·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·Christian H NickelRoland Bingisser
Sep 13, 2011·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·W Frank PeacockAlan S Maisel
Dec 12, 2012·Journal of Peptide Science : an Official Publication of the European Peptide Society·Yosuke SuzukiMasaharu Takeyama
Sep 10, 2014·European Journal of Heart Failure·Ralf KaiserTanja M Raedle-Hurst
Jun 28, 2005·Peptides·Joachim StruckAndreas Bergmann
Jul 22, 2014·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·W E van der StarreJ T van Dissel
Jul 31, 2007·Annales d'endocrinologie·B Müller

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