Identification of an alternatively spliced mRNA transcript of human betacellulin lacking the C-loop of the EGF motif and the transmembrane domain

Growth Factors
Andrew J Dunbar, C Goddard

Abstract

This paper describes the cloning and characterization of a novel cDNA encoding a short form of betacellulin (BTC-beta), and reports the expression of this mRNA in a variety of human tissues and cell types. BTC-beta is likely the result of alternative splicing. This splicing event leads to the generation of an mRNA encoding an unusual BTC precursor in which the C-loop of the EGF domain and the transmembrane domain are deleted while the remainder of the mature molecule is fused in-frame to the C-terminal cytoplasmic tail.

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Citations

Jul 5, 2005·Journal of Hepato-biliary-pancreatic Surgery·Satoko Yamada, Itaru Kojima
Jan 21, 2014·Seminars in Cell & Developmental Biology·Maik DahlhoffMarlon R Schneider
Jul 14, 2012·PloS One·Ernestina SaulleSimona Coppola

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