Identification of an attachment site for human liver plasma membranes on hepatitis B virus particles.

Virology
P PontissoA Alberti

Abstract

The surface antigen of hepatitis B virus (HBsAg) exposes three protein domains: preS1, preS2, and S. In a previous study we have shown that preS1 sequences expressed in transfected yeast cells bind specifically to plasma membranes of human liver. In this study we show that purified virus particles from a virus carrier bind also specifically to such membranes. Subviral HBsAg filaments which are rich in preS1 bind well too, while HBsAg 20-nm particles which contain small amounts of preS1 bind to a much lesser degree. The binding can be inhibited by a monoclonal antibody which recognizes a sequential epitope between amino acids 27 and 49 of the preS1 domain.

References

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Citations

Jan 27, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Z J GongS H Yap
Jan 1, 1995·Archives of Virology·M SidorkiewiczA Płucienniczak
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Jun 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Pei ZhangJ Wai-Kou Shih
May 23, 2007·Proceedings of the National Academy of Sciences of the United States of America·Seung-Wook ChiSeong Eon Ryu
Jul 15, 1999·FEBS Letters·W N Chen, C J Oon
Sep 1, 2009·FEBS Letters·Seung-Wook ChiSeong Eon Ryu
Aug 19, 2008·Autoimmunity Reviews·Patrizia PontissoAngelo Gatta
Sep 4, 2007·Protein Science : a Publication of the Protein Society·Seung-Wook ChiKyou-Hoon Han
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Mar 22, 2002·The Journal of General Virology·Anna KramvisMichael C Kew
Jan 3, 2015·Biochimica Et Biophysica Acta·Carmen L DelgadoFrancisco Gavilanes

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