Identification of an erythroid ATP-dependent aminophospholipid transporter

British Journal of Haematology
Eric Soupene, Frans A Kuypers

Abstract

The asymmetric distribution of amino-containing phospholipids in plasma membranes is essential for the function and survival of mammalian cells. Phosphatidylserine (PS) is restricted to the inner leaflet of plasma membranes by an ATP-dependent transport process. Exposure of PS on the surface of cells serves as a binding site for haemostatic factors, triggers cell-cell interaction and recognition by macrophages and phospholipases. Exposure of PS on the red cell surface plays a significant role in sickle cell pathology. We report the identification of two different isoforms of the aminophospholipid translocase, Atp8a1, or flippase, in the murine red blood cell membrane.

References

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Citations

Aug 21, 2012·Cell Biochemistry and Biophysics·Daiana M VotaDaniela C Vittori
Dec 25, 2007·Proceedings of the National Academy of Sciences of the United States of America·Eric SoupeneFrans A Kuypers
Apr 9, 2008·Current Opinion in Hematology·David L Daleke
Mar 26, 2011·Cold Spring Harbor Perspectives in Biology·Gerrit van Meer
Nov 21, 2007·Hematology·Frans A Kuypers
Mar 5, 2014·Hematology/oncology Clinics of North America·Frans A Kuypers
Jan 12, 2012·Biochimica Et Biophysica Acta·Tessy T SebastianTodd R Graham
Mar 17, 2009·Biochimica Et Biophysica Acta·Baby-Periyanayaki MuthusamyTodd R Graham
Jun 25, 2009·British Journal of Haematology·Latorya A BarberRobert S Franco
Mar 18, 2008·British Journal of Haematology·Ward Hagar, Elliott Vichinsky
Jul 28, 2011·IUBMB Life·Frances J Sharom
Oct 16, 2010·Cardiovascular Therapeutics·Sharon L HaleRobert A Kloner
Sep 30, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Wei DongBaosheng Li
Oct 30, 2012·Biochimica Et Biophysica Acta·Jonathan A ColemanRobert S Molday
Dec 10, 2016·Molecular Biology of the Cell·Madhavan ChalatRobert S Molday
Jul 28, 2016·Frontiers in Physiology·Jens P AndersenRobert S Molday
Jan 25, 2021·The Journal of Biological Chemistry·Kai ChenNishith Gupta
May 16, 2021·Proceedings of the National Academy of Sciences of the United States of America·Seunghyi KookSusan H Guttentag
Mar 4, 2009·Biochimica Et Biophysica Acta·Dineke E FolmerCoen C Paulusma

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