Identification of an immunosuppressive epitope of type II collagen that confers protection against collagen-induced arthritis.

The Journal of Experimental Medicine
L K MyersA H Kang

Abstract

We have previously reported that collagen-induced arthritis can be suppressed by intravenous injection of native type II (CII) but not type I collagen. We have now identified denatured fragments of CII capable of suppressing collagen-induced arthritis and inducing tolerance. Purified CII was cleaved with cyanogen bromide (CB), and the major resulting peptides were isolated. Female DBA/1 mice were administered OVA, native CII, or one of the CB peptides, intravenously, before immunization with native CII, 6 wk after immunization, mice tolerized with CII and CB11 had a markedly lower incidence of arthritis compared with controls. There was a correlation between the overall antibody response and the incidence of arthritis. In addition, animals tolerized with either CII or CB11 had a decreased antibody response not only to CII, but also to each of the other CB peptides tested. To identify the epitope involved in suppression of arthritis, five synthetic peptides, 21-26 amino acids in length, corresponding to selected regions of CB11, were generated. Each of the peptides was injected intravenously into mice before immunization. Only one of these, CB11 122-147, was capable of suppressing arthritis. In addition, mice given the synthetic...Continue Reading

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Citations

Apr 16, 2002·Arthritis and Rheumatism·L K MyersA H Kang
Jul 1, 1993·Agents and Actions·K InoueK Kimura
Jan 1, 1997·Life Sciences·L K MyersA H Kang
Jan 13, 1998·Immunology Today·R LiblauH O McDevitt
Aug 1, 1994·The Journal of Experimental Medicine·E MichaëlssonR Holmdahl
Jan 1, 1993·Microbiology and Immunology·S Tarutani
Jan 1, 1993·Scandinavian Journal of Immunology·M J JacobsW B van den Berg
Apr 1, 1995·Immunological Reviews·R HolmdahlU Brunsberg
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Jan 16, 2008·Expert Opinion on Biological Therapy·Thomas E IchimWei-Ping Min
Jun 1, 1993·Annals of Medicine·R HolmdahlE Vuorio
May 20, 2015·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Linda K MyersAndrew H Kang
Jun 5, 2010·Pediatric Diabetes·Carla J GreenbaumBarbara Brooks-Worrell
Feb 16, 2002·Clinical Immunology : the Official Journal of the Clinical Immunology Society·L K MyersA H Kang
Sep 10, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·B TangL K Myers
Apr 1, 1991·Immunology Today·E Sercarz, U Krzych
Nov 12, 2016·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jeoung-Eun ParkLinda K Myers
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Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lolita ZaliauskieneJames F Collawn
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·B TangL K Myers
Feb 21, 2018·Frontiers in Immunology·Berhane GhebrehiwetEllinor I B Peerschke
Jan 1, 1991·Arthritis and Rheumatism·S KobayashiM Taniguchi

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