PMID: 6980996Jul 1, 1982Paper

Identification of an inherited form of Peyronie's disease with autosomal dominant inheritance and association with Dupuytren's contracture and histocompatibility B7 cross-reacting antigens

The Journal of Urology
L M NybergP C Walsh

Abstract

Peyronie's disease is an inflammatory disorder with no confirmed etiology. We have documented the familial transmission of the disease as an autosomal dominant trait in 3 pedigrees. The occurrence of Dupuytren's contracture in 7 of 9 (78 per cent) affected individuals, which is a significant increase over the average 0 per cent reported in sporadic cases, suggests that both of these fibrosing disorders are pleiotropic effects of the same gene in these families. Similarly, the histocompatibility B7 cross-reacting antigens were present in 90 per cent of the patients with Peyronie's disease. Additional studies, including careful family histories and histocompatibility antigen typing, are necessary to elucidate the role of histocompatibility antigens as a relative risk factor.

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Citations

Nov 28, 2002·International Journal of Impotence Research·T F Lue
Jun 3, 2011·International Journal of Impotence Research·H M NugterenM F van Driel
Jun 14, 2019·World Journal of Urology·Darshan P PatelAlexander W Pastuszak
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Nov 16, 2004·Current Urology Reports·Mark JalkutJacob Rajfer
Jun 14, 2001·The Urologic Clinics of North America·S S Gholami, T F Lue

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