Identification of an intrinsic lysophosphatidic acid acyltransferase activity in the lipolytic inhibitor G0/G1 switch gene 2 (G0S2).

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Xiaodong ZhangJun Liu

Abstract

G0/G1 switch gene 2 (G0S2) is a specific inhibitor of adipose triglyceride lipase (ATGL), the rate-limiting enzyme for intracellular lipolysis. Recent studies show that G0S2 plays a critical role in promoting triacylglycerol (TG) accumulation in the liver, and its encoding gene is a direct target of a major lipogenic transcription factor liver X receptor (LXR)α. Here we sought to investigate a lipolysis-independent role of G0S2 in hepatic triglyceride synthesis. Knockdown of G0S2 decreased hepatic TG content in mice with ATGL ablation. Conversely, overexpression of G0S2 promoted fatty acid incorporation into TGs and diacylglycerols in both wild-type and ATGL-deficient hepatocytes. Biochemical characterization showed that G0S2 mediates phosphatidic acid synthesis from lysophosphatidic acid (LPA) and acyl-coenzyme A. In response to a high-sucrose lipogenic diet, G0S2 is up-regulated via LXRα and required for the increased TG accumulation in liver. Furthermore, deletion of a distinct 4-aa motif necessary for the LPA-specific acyltransferase (LPAAT) activity impaired G0S2's ability to mediate TG synthesis both in vitro and in vivo. These studies identify G0S2 as a dual-function regulator of lipid metabolism as well as a novel mecha...Continue Reading

References

Aug 8, 1997·The Journal of Biological Chemistry·C EberhardtL W Tjoelker
Jan 10, 2002·The Journal of Biological Chemistry·Kari Anne Risan TobinHilde Irene Nebb
Apr 23, 2002·Nature Genetics·Anil K AgarwalAbhimanyu Garg
Jul 22, 2004·Proceedings of the National Academy of Sciences of the United States of America·Guoxun ChenMichael S Brown
Nov 20, 2004·Science·Robert ZimmermannRudolf Zechner
Oct 28, 2008·Journal of Lipid Research·Rudolf ZechnerAchim Lass
Oct 29, 2008·Seminars in Liver Disease·Harmeet Malhi, Gregory J Gores
Apr 2, 2009·American Journal of Physiology. Endocrinology and Metabolism·Kazuharu Takeuchi, Karen Reue
Nov 26, 2009·The Journal of Biological Chemistry·Elin Holter AnthonisenLine M Grønning-Wang
Jul 22, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Weiqin ChenLawrence Chan
Oct 23, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kuok Teong OngDouglas G Mashek
Nov 12, 2010·Journal of Lipid Research·Mahesh K BasantaniErin E Kershaw
Apr 6, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jiang Wei WuGrant A Mitchell
Apr 16, 2011·Current Opinion in Lipidology·José M Lou-BonafonteJesús Osada
Jun 16, 2011·International Journal of Obesity : Journal of the International Association for the Study of Obesity·A Girousse, D Langin
Jun 28, 2011·Science·Jonathan C CohenHelen H Hobbs
Mar 13, 2012·Cell Metabolism·Rudolf ZechnerFrank Madeo
Feb 22, 2014·Cancer Biology & Therapy·Tian MaEthan Dmitrovsky
Sep 27, 2014·The Journal of Biological Chemistry·Ines K CerkMonika Oberer
Oct 30, 2014·American Journal of Physiology. Endocrinology and Metabolism·Charlotte J GreenLeanne Hodson
Nov 22, 2014·Biology·Atsushi YamashitaTakayuki Sugiura
Apr 10, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Douglas G MashekMallory P Franklin
Oct 29, 2015·Proceedings of the National Academy of Sciences of the United States of America·Renate SchreiberRudolf Zechner
Dec 16, 2016·International Journal of Molecular Sciences·Salvatore PettaFerruccio Bonino

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