Identification of an oral microbiota signature associated with an impaired orosensory perception of lipids in insulin-resistant patients.

Acta Diabetologica
Philippe BesnardRémy Burcelin

Abstract

Type 2 diabetes leads to multiple sensory dysfunctions affecting notably the gustatory sensitivity. Although this sensory defect, by impacting food choices, might lead to unhealthy eating behavior, underlying mechanisms remains poorly studied. We have recently reported that the composition of microbiota in contact with circumvallate gustatory papillae might affect the orosensory perception of lipids in lean and normoglycemic obese subjects. This finding has prompted us to explore whether such a phenomenon also occurs in diabetic obese patients. The composition of microbiota surrounding the circumvallate papillae was analyzed in combination with the linoleic acid perception thresholds in male insulin-resistant patients and weight-matched healthy controls. Two complementary comparisons were performed: (1) controls vs diabetic and (2) diabetic low-lipid tasters versus diabetic high-lipid tasters. Despite subtle modifications in the oral microbiota composition, comparison of orosensory lipid perception in controls and diabetic subjects did not lead to discriminating data due to the large inter-individual variability of linoleic acid perception thresholds. In contrast, specific bacterial signatures were found by comparing diabetic l...Continue Reading

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Citations

Jul 13, 2021·Journal of Parkinson's Disease·Manon AuffretMarc Vérin
Aug 28, 2021·Nutrients·Ryan Leung, Mihai Covasa

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Methods Mentioned

BETA
PCR

Clinical Trials Mentioned

NCT02028975

Software Mentioned

PICRUSt
HumanFATaste
PRISM
LEfSe
RDP Classifier
R

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