Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs

Journal of Agricultural and Food Chemistry
Wilhelmina KaltPaul E Milbury

Abstract

Dietary intervention with anthocyanins may confer benefits in brain function, including vision. Research to date indicates that animals have only a limited capacity to absorb anthocyanins, compared to other types of flavonoids. Pigs, which are a suitable model for human digestive absorption, were used to examine the deposition of anthocyanins in tissues including the liver, eye, and brain tissue. Pigs were fed diets supplemented with 0, 1, 2, or 4% w/w blueberries ( Vaccinium corymbosum L. 'Jersey') for 4 weeks. Prior to euthanasia, pigs were fasted for 18-21 h. Although no anthocyanins were detected in the plasma or urine of the fasted animals, intact anthocyanins were detected in all tissues where they were sought. LC-MS/MS results are presented for the relative concentration of 11 intact anthocyanins in the liver, eye, cortex, and cerebellum. The results suggest that anthocyanins can accumulate in tissues, including tissues beyond the blood-brain barrier.

Citations

Feb 9, 2012·European Journal of Nutrition·Lucélia TavaresCláudia N Santos
Jun 19, 2012·Molecular Neurobiology·Sebastian SchafferGunter P Eckert
Oct 22, 2008·Genes & Nutrition·David VauzourJeremy P E Spencer
Dec 24, 2009·The British Journal of Nutrition·Robert KrikorianJames A Joseph
Mar 2, 2010·The British Journal of Nutrition·Catherine FelginesOdile Texier
Oct 20, 2010·The British Journal of Nutrition·Daniele Del RioAlan Crozier
Mar 15, 2012·The Proceedings of the Nutrition Society·Catarina RendeiroJeremy P E Spencer
Nov 25, 2011·Journal of Agricultural and Food Chemistry·Mary Ann LilaMary H Grace
Jan 24, 2012·Journal of Agricultural and Food Chemistry·Marshall G Miller, Barbara Shukitt-Hale
Apr 4, 2012·Journal of Agricultural and Food Chemistry·Robert KrikorianSara Sadat-Hossieny
Jan 6, 2010·Journal of Agricultural and Food Chemistry·Robert KrikorianJames A Joseph
Aug 15, 2012·Journal of Nutrition in Gerontology and Geriatrics·Paul E Milbury
Nov 1, 2010·Nutrients·David VauzourJeremy P E Spencer
Jan 3, 2012·Advances in Nutrition·Taylor C Wallace
Oct 23, 2014·Journal of Agricultural and Food Chemistry·Wilhelmina KaltFrancois Tremblay
Aug 1, 2008·Nutrition Reviews·Michael Rhone, Arpita Basu
Oct 28, 2014·Drug Metabolism Reviews·Jim Fang
Mar 25, 2015·Journal of the Science of Food and Agriculture·Petra KšonžekováL'udmila Tkáčiková
Feb 19, 2016·Journal of Alzheimer's Disease : JAD·Abdenour Belkacemi, Charles Ramassamy
Dec 12, 2012·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Diana E RoopchandIlya Raskin
Jul 27, 2012·The Journal of Nutritional Biochemistry·François TremblayWilhelmina Kalt
Jan 10, 2016·Neurotoxicity Research·Susana AlmeidaBranca M Silva
Jan 17, 2016·Annual Review of Food Science and Technology·Mary Ann LilaWilhelmina Kalt
Oct 20, 2015·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Maharshi BhaswantLindsay Brown
Mar 12, 2016·Behavioural Brain Research·Manuela MeirelesConceição Calhau
Jan 16, 2016·Oxidative Medicine and Cellular Longevity·A J CaseM C Zimmerman
Sep 30, 2015·Journal of the Science of Food and Agriculture·Bettina FaehnrichQendrim Zebeli
Sep 1, 2015·The Journal of Nutritional Biochemistry·Manuela MeirelesConceição Calhau
Aug 5, 2009·Molecular Nutrition & Food Research·Catherine FelginesAugustin Scalbert

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier Regulation in Health & Disease

The blood brain barrier is essential in regulating the movement of molecules and substances in and out of the brain. Disruption to the blood brain barrier and changes in permeability allow pathogens and inflammatory molecules to cross the barrier and may play a part in the pathogenesis of neurodegenerative disorders. Here is the latest research in this field.

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.

Blood Brain Barrier Chips

The blood brain barrier (BBB) is comprised of endothelial cells that regulate the influx and outflux of plasma concentrations. Lab-on-a-chip devices allow scientists to model diseases and mechanisms such as the passage of therapeutic antibodies across the BBB. Discover the latest research on BBB chips here.