Identification of anticoagulant activities in salivary gland extracts of four horsefly species (Diptera, tabanidae)

Haemostasis
M KazimírováP A Nuttall

Abstract

Anticoagulant activities against the extrinsic and intrinsic coagulation pathways were identified in salivary gland extracts (SGE) prepared from four tabanids (Hybomitra muehlfeldi, Tabanus autumnalis, Haematopota pluvialis, Heptatoma pellucens). All extracts prolonged human plasma clotting time in a dose-dependent manner and inhibited thrombin activity in the chromogenic substrate assay. Horsefly SGE did not inhibit factor Xa. Partial purification of SGE proteins using reversed-phase high-performance liquid chromatography revealed species-specific differences in the elution profiles and range of fractions with anticoagulant activities.

Citations

Jun 8, 2006·Archives of Pharmacal Research·Mi Young AhnYeong Shik Kim
Sep 24, 2002·Medical and Veterinary Entomology·M KazimírováP A Nuttall
Jun 18, 2009·Molecular & Cellular Proteomics : MCP·Dongying MaRen Lai
Aug 3, 2012·Biological Psychiatry·Cristina Alba-DelgadoEsther Berrocoso
Jul 29, 2009·Toxicon : Official Journal of the International Society on Toxinology·Dongying MaRen Lai
Apr 1, 2009·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Ruili ZhaoJingze Liu
May 27, 2008·Developmental and Comparative Immunology·Xiuwen YanRen Lai
Sep 16, 2015·Insect Biochemistry and Molecular Biology·José M C RibeiroIvo M B Francischetti
Dec 4, 2003·Medical and Veterinary Entomology·P RajskáP A Nuttall
Jan 15, 2008·International Journal of Laboratory Hematology·S E RodgersJ V Lloyd
Dec 21, 2007·Medical and Veterinary Entomology·P RajskáP A Nuttall
Sep 4, 2014·Asian Pacific Journal of Tropical Biomedicine·Subhalaxmi BorahManab Deka
Jan 5, 2006·The Journal of Experimental Biology·Peter TakácMilan Labuda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.