Abstract
Angiotensin-converting enzyme (ACE) inhibitory activity was evaluated for the low-molecular-weight fraction (<3 kDa) obtained from milk fermentation by Bifidobacterium longum KACC91563. The ACE inhibitory activity in this fraction was 62.3%. The peptides generated from the <3 kDa fraction were identified by liquid chromatography-electrospray ionization quantitative time-of-flight mass spectrometry analysis. Of the 28 peptides identified, 11 and 16 were identified as β-casein (CN) and αs1-CN, respectively. One peptide was identified as κ-CN. Three peptides, YQEPVLGPVRGPFPIIV, QEPVLGPVRGPFPIIV, and GPVRGPFPIIV, from β-CN corresponded to known antihypertensive peptides. We also found 15 peptides that were identified as potential antihypertensive peptides because they included a known antihypertensive peptide fragment. These peptides were as follows: RELEELNVPGEIVE (f1-14), YQEPVLGPVRGPFP (f193-206), EPVLGPVRGPFPIIV (f195-206), PVLGPVRGPFPIIV (f196-206), VLGPVRGPFPIIV (f197-206), and LGPVRGPFPIIV (f198-206) for β-CN; and APSFSDIPNPIGSENSEKTTMPLW (f176-199), SFSDIPNPIGSENSEKT- TMPLW (f178-199), FSDIPNPIGSENSEKTTMPLW (f179-199), SDIPNPIGSENSEKTTMPLW (f180-199), DIPNPIGSENSEKTTMPLW (f181-199), IPNPIGSENSEKTTMPLW (f182-199), PIGSENSEKT...Continue Reading
References
Jul 1, 1971·Biochemical Pharmacology·D W Cushman, H S Cheung
Jan 1, 1982·Medicinal Research Reviews·E W Petrillo, M A Ondetti
Apr 1, 1994·Journal of Dairy Science·N YamamotoT Takano
Mar 7, 1996·Biochimica Et Biophysica Acta·A KaspariH U Demuth
Jun 1, 1996·Journal of Bacteriology·C GilbertB Mollet
Aug 1, 1996·Journal of Dairy Science·M MaenoT Takano
May 1, 1999·Applied and Environmental Microbiology·E TsakalidouG Kalantzopoulos
May 8, 1999·The American Journal of Clinical Nutrition·M D Collins, G R Gibson
May 3, 2000·Journal of Dairy Science·R H DavidsonJ W Boling
Aug 31, 2000·Applied and Environmental Microbiology·M GobbettiF Addeo
Jun 13, 2002·Critical Reviews in Food Science and Nutrition·M GobbettiR Di Cagno
Nov 6, 2002·FEBS Letters·Jérôme TauzinJean Luc Gaillard
Oct 9, 2003·Applied and Environmental Microbiology·Irena PastarGoran Jovanovic
Jan 30, 2004·The American Journal of Clinical Nutrition·Jose M SaavedraRobert H Yolken
May 27, 2005·Journal of Applied Microbiology·S C LeahyD van Sinderen
Dec 8, 2005·Applied and Environmental Microbiology·C JanerT Requena
Aug 11, 2006·Journal of Dairy Science·S V SilvaF X Malcata
Apr 5, 2007·Biotechnology Journal·Maria HayesR Paul Ross
May 8, 2007·Applied and Environmental Microbiology·M HayesR P Ross
Apr 22, 2008·Applied and Environmental Microbiology·Elvira María HebertFrancesco Addeo
Mar 17, 2009·Applied and Environmental Microbiology·M GenayS Lortal
Jun 9, 2009·International Journal of Food Microbiology·Lorena RuizAbelardo Margolles
Nov 3, 2010·Applied and Environmental Microbiology·L Sadat-MekmeneV Gagnaire
Mar 1, 2011·International Journal of Food Microbiology·Leila Sadat-MekmeneValérie Gagnaire
Jul 12, 2011·Journal of Bacteriology·Jun-Sang HamHeebal Kim
Nov 23, 2011·Journal of Agricultural and Food Chemistry·Laurent MicloAnnie Dary
Jul 23, 2013·Journal of Dairy Science·O K ChangJ-S Ham
Oct 19, 2013·International Journal of Food Microbiology·Cid Gonzalez-GonzalezPaula Jauregi
Jul 23, 2014·Asian-Australasian Journal of Animal Sciences·M A IslamG E Vegarud
Citations
Aug 8, 2018·Marine Drugs·Jianpeng LiHaohao Wu
Nov 16, 2019·Food Science of Animal Resources·Nam Su OhYounghoon Kim
Oct 21, 2017·Journal of Food Science and Technology·Katarzyna SkrzypczakAdam Waśko
Mar 9, 2018·Analytical and Bioanalytical Chemistry·Dominic AgyeiChibuike C Udenigwe
Jan 23, 2019·Applied Microbiology and Biotechnology·B LiK J Heller
Jul 28, 2017·Korean Journal for Food Science of Animal Resources·Sang Hoon KimDae-Kyung Kang
Nov 30, 2018·Food Science and Biotechnology·Eric Banan-Mwine DaliriDeog-Hwan Oh
Nov 5, 2019·Frontiers in Nutrition·Eman AliGisèle LaPointe
Jun 13, 2017·Critical Reviews in Food Science and Nutrition·Eric Banan-Mwine DaliriDeog H Oh
Oct 22, 2020·Nutrients·Brian ChristensenEsben S Sørensen
Nov 26, 2020·International Journal of Molecular Sciences·Akanksha TyagiDeog-Hwan Oh
Dec 19, 2020·Comprehensive Reviews in Food Science and Food Safety·Kong Fei ChaiWei Ning Chen
Jul 14, 2020·Food Chemistry·Flávia Giacometti CavalheiroMirna Lúcia Gigante
Mar 12, 2020·Journal of Agricultural and Food Chemistry·Fidel ToldráLeticia Mora