Identification of Asian genotype of chikungunya virus isolated in Mexico

Virus Genes
José Alberto Díaz-QuiñonezJosé Ernesto Ramírez-González

Abstract

We identified 25 autochthonous chikungunya virus cases in Mexico, initially detected by RT-PCR targeting the E1 gene and propagated in C6/36 Aedes albopictus cells, in 2014. To determine the type of virus found, in a previous report, the genomes of 2 CHIKV strains were fully sequenced. Genome sequence analysis revealed that these isolates from Mexico belonged to the Asian genotype, and a phylogenetic association with the circulating strain in the British Virgin Islands was also established in the same year. This was further supported by changes in specific amino acids, E2-V368A and 6K-L20M. For these reasons, it can be inferred that the route of virus entry to Mexico was held across the countries in the Caribbean and Central America. The presence of E1-A226V mutation associated with more efficient replication in the salivary gland of the A. albopictus mosquito was not observed. Interestingly, a newly acquired NSP4-S399C mutation was observed; however, the significance of changes in amino acid found in non-structural proteins in autochthonous strains remains to be elucidated.

References

Jun 2, 2010·Clinics in Laboratory Medicine·Ann M Powers
Aug 24, 2013·Emerging Infectious Diseases·Paul F HorwoodBoris I Pavlin
Jul 31, 2014·Emerging Infectious Diseases·Robert S Lanciotti, Anne Marie Valadere

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Citations

Apr 19, 2016·Emerging Infectious Diseases·José Alberto Díaz-QuiñonezJosé Ernesto Ramírez-González
Mar 16, 2017·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Braira WahidMuhammad Idrees
Aug 9, 2017·International Journal of Environmental Research and Public Health·Oliver Mendoza-CanoEfrén Murillo-Zamora
Aug 19, 2017·Viruses·Jolene Ramsey, Suchetana Mukhopadhyay
Mar 27, 2018·International Journal of Immunogenetics·J J López-JiménezH Montoya-Fuentes
May 11, 2021·Frontiers in Cellular and Infection Microbiology·Yusnita Mirna AnggraeniRoger Frutos
Aug 29, 2021·Pathogens·Margarita V Rangel, Kenneth A Stapleford

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