Identification of autoantibodies elicited in a patient with prostate cancer presenting as dermatomyositis

International Journal of Urology : Official Journal of the Japanese Urological Association
Colin J MooneyD G McNeel

Abstract

Dermatomyositis is an uncommon autoimmune disease distinguished by proximal muscle weakness and a characteristic skin rash. Dermatomyositis has also frequently been associated with malignancy, typically heralding the diagnosis of ovarian, lung, gastric, or colorectal cancer. We report an unusual case of prostate adenocarcinoma preceded by a diagnosis of dermatomyositis. We hypothesized that in this particular patient, proteins produced by the neoplastic prostatic tissue, which might be normally expressed in muscle tissue, were immunologically recognized as autoantigens. Serum from this patient was used to screen a cDNA lambda phage expression library from normal prostate tissue for prostate protein-specific IgG. We identified several immunoreactive plaques encoding known autoantigens, and several encoding known muscle-related proteins, including aldolase C, eukaryotic translation elongation factor 1 alpha 1, transgelin, and acetyl-coenzyme A acyltransferase 1. IgG specific for these proteins were not specifically recognized in sera from other patients with prostate cancer compared with male control blood donors, and were not specifically recognized in a small panel of sera from patients with breast or ovarian cancer and dermato...Continue Reading

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Citations

Jun 2, 2010·Cancer Immunology, Immunotherapy : CII·A HellerN A Giese
Jan 5, 2011·Journal of Biomedicine & Biotechnology·Heath A SmithDouglas G McNeel
Feb 20, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Douglas G McNeel
Sep 2, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jian Jun GaoDouglas G McNeel
Feb 27, 2016·Clinics and Practice·Takeshi KusunokiRyo Wada
Nov 23, 2021·Journal of Clinical Neuromuscular Disease·Corinna E PsomadakisStephen N Scelsa

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