PMID: 9557164Apr 29, 1998Paper

Identification of autoimmune thrombocytopenic purpura-related epitopes using phage-display peptide library

Clinical Immunology and Immunopathology
G GevorkianV Dominguez

Abstract

A random heptapeptide phage-displayed library was screened with two serum samples from autoimmune thrombocytopenic purpura (AITP) patients to address the repertoire of autoantigenic epitopes involved in platelet destruction. We obtained a panel of affinity-selected phage clones that have been shown to react in enzyme-linked immunosorbent assay with autoantibodies from other AITP patients. None of the peptides obtained has been described previously as possibly being an epitope for antiplatelet antibodies, and the majority of them did not show any homology with known platelet glycoproteins. We conclude that peptides identified in this study could represent discontinuous epitopes or mimotopes of natural autoantigens. Also, they could be present in still-unknown proteins involved in AITP pathogenesis.

References

Aug 10, 1992·Journal of Immunological Methods·J A LenstraK K Stanley
Jul 27, 1990·Science·J K Scott, G P Smith
Jan 1, 1990·Annual Review of Biochemistry·D R DaviesS Sheriff
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·S E CwirlaW J Dower
Nov 1, 1987·British Journal of Haematology·T TsubakioR McMillan
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M BalassS Fuchs
Jul 1, 1994·British Journal of Haematology·P BierlingN Duedari
Sep 1, 1995·British Journal of Haematology·R D BowditchR McMillan
Dec 30, 1994·Gene·S J McConnellR H Hoess
Jan 1, 1996·Methods in Enzymology·F FeliciR Cortese

❮ Previous
Next ❯

Citations

May 21, 2005·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Yetzi RoblesKaren Manoutcharian
Sep 18, 2002·Archives of Medical Research·Edda SciuttoCarlos Larralde
Jan 21, 2016·Journal of Biomedical Science·Chien-Hsun WuHan-Chung Wu
Jul 30, 2011·Clinical and Experimental Immunology·K MitsuyamaM Sata
Aug 22, 2012·Human Vaccines & Immunotherapeutics·Justyna BazanAndrzej Gamian
Apr 29, 1999·Clinical Immunology : the Official Journal of the Clinical Immunology Society·K ManoutcharianG Gevorkian
Nov 25, 2004·The Biochemical Journal·Goar GevorkianLuz M López-Marín
Dec 1, 2001·Clinical Immunology : the Official Journal of the Clinical Immunology Society·H SantamariaG Gevorkian
Feb 22, 2001·Methods : a Companion to Methods in Enzymology·K A Noren, C J Noren

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Bacteriophage: Phage Therapy

Phage therapy uses bacterial viruses (bacteriophages) to treat bacterial infections and is widely being recognized as an alternative to antibiotics. Here is the latest research.

© 2022 Meta ULC. All rights reserved