PMID: 9185969Jun 1, 1997Paper

Identification of beta-adrenergic receptor subtypes mediating relaxation in isolated equine ileum

American Journal of Veterinary Research
G ReC Beretta

Abstract

To identify beta-adrenergic receptor subtypes in ileum smooth muscle of the horse. Isolated strips of equine longitudinal ileum smooth muscle and membrane preparations from smooth muscle of the intestinal wall. Functional assays and radioligand binding assays. Relaxation of ileum longitudinal smooth muscle proved to be mainly caused by stimulation of beta-atypical and beta 2-adrenergic receptors. Binding studies on cell membranes indicated that the total beta-adrenergic receptors population consists of 54% beta-atypical, 34% beta 2- and 12% beta 1-subtypes. The data suggest that sympathetic relaxation of equine ileum smooth muscle depends mainly on beta-atypical receptor subtypes activation, with a minor contribution by beta 2-subtypes. The important role of beta-atypical adrenergic receptor subtypes in the relaxation of equine ileum suggests possible clinical use of selective beta-atypical receptor agonists to control intestinal disturbances.

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