Identification of bioactive metabolites using activity metabolomics

Nature Reviews. Molecular Cell Biology
Markus M RinschenGary Siuzdak

Abstract

The metabolome, the collection of small-molecule chemical entities involved in metabolism, has traditionally been studied with the aim of identifying biomarkers in the diagnosis and prediction of disease. However, the value of metabolome analysis (metabolomics) has been redefined from a simple biomarker identification tool to a technology for the discovery of active drivers of biological processes. It is now clear that the metabolome affects cellular physiology through modulation of other 'omics' levels, including the genome, epigenome, transcriptome and proteome. In this Review, we focus on recent progress in using metabolomics to understand how the metabolome influences other omics and, by extension, to reveal the active role of metabolites in physiology and disease. This concept of utilizing metabolomics to perform activity screens to identify biologically active metabolites - which we term activity metabolomics - is already having a broad impact on biology.

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Methods Mentioned

BETA
chemical
acetylation
glycosylation
acylation
NMR
immunoprecipitation
thermal shift
pull-down
phosphotransferase

Software Mentioned

MetaboAnalyst
Metabolomics Workbench
XCMS Online
Biocyc
MetExplore
ChEMBL
MetaboLights
XCMS
METLIN
Recon

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