PMID: 11918691Mar 29, 2002Paper

Identification of broadly recognized, T helper 1 lymphocyte epitopes in an equine lentivirus

Immunology
D G FraserT C McGuire

Abstract

Equine infectious anaemia virus (EIAV) is a horse lentivirus causing lifelong, persistent infection. During acute infection, CD8(+) cytotoxic T lymphocytes (CTL) are probably involved in terminating plasma viraemia. However, only a few EIAV CTL epitopes, restricted to fewer horse major histocompatibility complex (MHC) class I alleles, are known. As interferon-gamma (IFN-gamma)-secreting CD4(+), T helper 1 (Th1) lymphocytes promote CTL activity and help maintain memory CTL, identifying broadly recognized EIAV Th1 epitopes would contribute significantly to vaccine strategies seeking to promote strong CTL responses among horses with varying class I haplotypes. To this end, peripheral blood mononuclear cells (PBMC) from 10 MHC disparate, EIAV-infected horses were tested in T-lymphocyte proliferation assays for recognition of peptides from the Gag p26 capsid region and a portion of Pol. Both regions are highly conserved among EIAV isolates, and this Pol region is 51-63% homologous to other lentiviral Pol proteins. Seven of 10 horses recognized peptide Gag 221-245, and peptides Gag 242-261 and Pol 323-344 were recognized by five and four horses, respectively. Furthermore, the Gag peptides were recognized by two additional horses afte...Continue Reading

References

Mar 1, 1990·International Journal of Peptide and Protein Research·G B Fields, R L Noble
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R A OlmstedP R Johnson
Jan 1, 1973·Archiv für die gesamte Virusforschung·Y KonoY Fukunaga
Jan 1, 1996·Immunogenetics·D G Fraser, E Bailey
Sep 1, 1996·The Journal of Experimental Medicine·R D CardinP C Doherty
Jan 1, 1996·Immunogenetics·D G Albright-FraserE Bailey
Jun 20, 1998·Immunogenetics·D G Fraser, E Bailey
Feb 9, 1999·Veterinary Immunology and Immunopathology·S Giguère, J F Prescott
Nov 26, 1999·Proceedings of the National Academy of Sciences of the United States of America·M C GauduinR P Johnson
Feb 13, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·S M VargaR M Welsh

❮ Previous
Next ❯

Citations

Jun 30, 2005·Animal Health Research Reviews·Travis C McGuireRobert H Mealey
Sep 9, 2009·Veterinary Immunology and Immunopathology·K SatuéJ E O'Connor
Aug 21, 2007·Journal of Molecular Recognition : JMR·Adriana SoutulloGeorgina G Tonarelli
Aug 18, 2005·Veterinary Immunology and Immunopathology·A SoutulloI Malan Borel
Jan 16, 2013·Journal of Virological Methods·Bazartseren BoldbaatarHiroshi Sentsui
Sep 24, 2016·Applied Microbiology and Biotechnology·Zhe HuXiaojun Wang
Aug 9, 2005·Clinical and Diagnostic Laboratory Immunology·Darrilyn G FraserTravis C McGuire

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.