Identification of candidate biomarker mass (m/z) ranges in serous ovarian adenocarcinoma using matrix-assisted laser desorption/ionization time-of-flight mass spectrometry profiling

Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
Amutha PeriyasamyRajkumar Thangarajan

Abstract

To differentiate plasma from ovarian cancer and healthy individuals using MALDI-TOF mass spectroscopy. MALDI-TOF was used to generate profiles of immuno-depleted plasma samples (89 cancers and 199 healthy individuals) that were fractionated using three types of magnetic beads (HIC8, WCX and IMAC-Cu). Differentially expressed mass ranges showing >1.5-2-fold change in expression from HIC8 (30), WCX (12) and IMAC-Cu (6) fractions were identified. Cross validation and recognition capability scores for the models indicated discrimination between the classes. Spectral profiles can differentiate plasma samples of ovarian cancer patients from healthy individuals.

References

Dec 19, 2002·Molecular & Cellular Proteomics : MCP·N Leigh Anderson, Norman G Anderson
Mar 27, 2003·Medical Electron Microscopy : Official Journal of the Clinical Electron Microscopy Society of Japan·Tsunehisa KakuHitoo Nakano
Aug 19, 2008·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Kyoko KojimaJohn D Christein
Jul 1, 2008·Proteomics. Clinical Applications·Niccolò BossoFulvio Magni
Apr 28, 2011·CA: a Cancer Journal for Clinicians·Danijela Jelovac, Deborah K Armstrong
Jan 11, 2013·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Paulo OrnellasFulvio Magni

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Citations

May 3, 2016·Clinica Chimica Acta; International Journal of Clinical Chemistry·Joanna HajdukZenon J Kokot
Oct 3, 2018·Journal of Ovarian Research·Agata SwiatlyZenon J Kokot

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