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Identification of candidate drugs using tensor-decomposition-based unsupervised feature extraction in integrated analysis of gene expression between diseases and DrugMatrix datasets

Scientific Reports

Oct 25, 2017

Y-H Taguchi

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Abstract

Identifying drug target genes in gene expression profiles is not straightforward. Because a drug targets proteins and not mRNAs, the mRNA expression of drug target genes is not always altered. In addition, the interaction between a drug and protein can be context dependent; this means t...read more

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Genes
Cirrhosis
Candidate Disease Gene
Research Personnel
Substance Abuse Detection
Bezafibrate
POR gene
Gene Expression
Docking -molecular Interaction
Pharmacologic Substance
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Identification of candidate drugs using tensor-decomposition-based unsupervised feature extraction in integrated analysis of gene expression between diseases and DrugMatrix datasets

Scientific Reports

Oct 25, 2017

Y-H Taguchi

PMID: 29062063

DOI: 10.1038/s41598-017-13003-0

Abstract

Identifying drug target genes in gene expression profiles is not straightforward. Because a drug targets proteins and not mRNAs, the mRNA expression of drug target genes is not always altered. In addition, the interaction between a drug and protein can be context dependent; this means t...read more

Mentioned in this Paper

Genes
Cirrhosis
Candidate Disease Gene
Research Personnel
Substance Abuse Detection
Bezafibrate
POR gene
Gene Expression
Docking -molecular Interaction
Pharmacologic Substance
6
10
1

Feeds With Similar Papers

Drug & Digital Interventions

This feed describes how digital interventions, which are digital and mobile technologies used to support health system needs, can complement and improve pharmacotherapy in disease management. Discover the latest research on drug and digtial intervention here,

Addiction

This feed focuses mechanisms underlying addiction and addictive behaviour including heroin and opium dependence, alcohol intoxication, gambling, and tobacco addiction.

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Paper Details
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  • Citations2
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    References currently unavailable

    We're still populating references for this paper, please check back later.
  • References
  • Citations2
1

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