Identification of central nervous system neurons innervating the respiratory muscles of the mouse: a transneuronal tracing study

Brain Research Bulletin
Susana P GaytánGérard Hilaire

Abstract

In recent years, the central control of breathing in mammals has been the subject of numerous studies. The aim of the present one was to characterize the neuronal network projecting to the main respiratory motoneurons, in adult mice. To this end, the morphology and location of the respiratory motoneurons and their sequential connections with other neurons were revealed using a transneuronal tracing technique by means of the rabies virus infection. The injections of the rabies virus in the respiratory muscles resulted in labeling the motoneurons and their serially connected interneurons at multiple levels of the mouse central nervous system: spinal cord, pons and medulla, cerebellum, mesencephalon, diencephalon, and telencephalon. Most of these labeled areas have been previously identified in the control of cardiorespiratory regulation, as well as in other autonomic functions. These anatomical data provide support for the integration of respiratory-related activities in complex behavioral responses. Furthermore, these data suggest similarities in the evolution of central respiratory networks in mammals.

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Citations

Jul 26, 2011·Respiratory Physiology & Neurobiology·Michael A Lane
Sep 8, 2010·Experimental Neurology·K QiuD D Fuller
Jun 10, 2009·Respiratory Physiology & Neurobiology·Angelina Y FongWilliam K Milsom
Aug 29, 2009·Respiratory Physiology & Neurobiology·Sebastien ZanellaFrancoise Muscatelli
Jul 19, 2008·Respiratory Physiology & Neurobiology·Jean-Charles Viemari
Dec 25, 2007·Respiratory Physiology & Neurobiology·Georg M StettnerMathias Dutschmann
Apr 14, 2005·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Margaret Seto-PoonChong Lee Lim
Nov 3, 2004·Respiratory Physiology & Neurobiology·Gérard HilaireMichelle Bévengut
Jul 1, 2008·Advances in Virus Research·Susan A Nadin-Davis, Christine Fehlner-Gardiner
Oct 17, 2003·Journal of Neurophysiology·Jean-Charles ViemariGérard Hilaire
Nov 24, 2004·Journal of Applied Physiology·John K YoungMusa A Haxhiu
Jan 18, 2003·News in Physiological Sciences : an International Journal of Physiology Produced Jointly by the International Union of Physiological Sciences and the American Physiological Society·Gérard Hilaire, Rosario Pásaro
Apr 6, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Luciane H GargaglioniWilliam K Milsom
Oct 21, 2006·Journal of Applied Physiology·Julian P SaboiskyJane E Butler
Sep 17, 2017·Nature Communications·Jinjin WuGilles Fortin
Jan 29, 2016·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Brian J KoosLawrence Kruger

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