Identification of changes in neuronal function as a consequence of aging and tauopathic neurodegeneration using a novel and sensitive magnetic resonance imaging approach

Neurobiology of Aging
Sarah N FontaineJose F Abisambra

Abstract

Tauopathies, the most common of which is Alzheimer's disease (AD), constitute the most crippling neurodegenerative threat to our aging population. Tauopathic patients have significant cognitive decline accompanied by irreversible and severe brain atrophy, and it is thought that neuronal dysfunction begins years before diagnosis. Our current understanding of tauopathies has yielded promising therapeutic interventions but have all failed in clinical trials. This is partly due to the inability to identify and intervene in an effective therapeutic window early in the disease process. A major challenge that contributes to the definition of an early therapeutic window is limited technologies. To address these challenges, we modified and adapted a manganese-enhanced magnetic resonance imaging (MEMRI) approach to provide sensitive and quantitative power to detect changes in broad neuronal function in aging mice. Considering that tau tangle burden correlates well with cognitive impairment in Alzheimer's patients, we performed our MEMRI approach in a time course of aging mice and an accelerated mouse model of tauopathy. We measured significant changes in broad neuronal function as a consequence of age, and in transgenic mice, before the ...Continue Reading

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Citations

Mar 24, 2018·International Journal of Molecular Sciences·Nicole CortésRicardo B Maccioni
Jan 30, 2018·Frontiers in Neurology·Naruhiko SaharaTetsuya Suhara
Aug 31, 2017·Aging·Ryan CloydJose F Abisambra
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Feb 4, 2021·International Journal of Molecular Sciences·Shon A KorenJose F Abisambra
May 25, 2021·Experimental Neurology·Ryan A CloydBret N Smith

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