Abstract
Chlamydia pneumoniae is an obligate intracellular pathogen responsible for respiratory diseases, including pneumonia and bronchitis, and is highly involved in chronic diseases, including atherosclerosis, asthma, and Alzheimer's disease. We previously showed that the host apoptotic factor caspase-9 played a crucial role for chlamydial multiplication and host apoptosis inhibition by chlamydial infection. To identify chlamydial genes interacting with human caspase-9, yeast two-hybrid screening was performed and 5 chlamydial genes, including Cpj0838 and pmpG were isolated from the C. pneumoniae genomic library. Pull-down experiments showed that caspase-9 physically bound to the Cpj0838 product and chlamydial cells, which contain PmpG proteins. This study could provide a clue to understanding host-Chlamydia interactions, especially the apoptosis repression by Chlamydia infection.
References
Jul 17, 1986·The New England Journal of Medicine·J T GraystonJ Altman
May 23, 1995·Proceedings of the National Academy of Sciences of the United States of America·Y AzumaM Nomura
Mar 28, 1998·The Journal of Experimental Medicine·T FanG Zhong
Sep 28, 1998·Medical Microbiology and Immunology·B J BalinA P Hudson
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y GengA H Rook
May 10, 2000·FEMS Microbiology Letters·P H MygindS Birkelund
Jun 6, 2000·The Journal of Infectious Diseases·M E RosenfeldC Kuo
Jul 6, 2000·Trends in Microbiology·L Y Gao, Y A Kwaik
Oct 24, 2002·The Journal of Biological Chemistry·Marco TafaniJohn L Farber
Jun 20, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robert J BellandHarlan D Caldwell
Aug 1, 1958·The British Journal of Ophthalmology·M J GILKESJ SOWA
Dec 16, 2003·Proceedings of the National Academy of Sciences of the United States of America·Robert J BellandHarlan D Caldwell
Dec 26, 2003·International Journal of Medical Microbiology : IJMM·Christian WahlAndreas Essig
Sep 29, 2004·The Journal of Experimental Medicine·Silke F FischerGeorg Häcker
May 3, 2005·The Journal of Biological Chemistry·Shirley M L TseSergio Grinstein
Sep 24, 2005·Infection and Immunity·John T BuchananVictor Nizet
May 20, 2006·PLoS Pathogens·Philippe VerbekeDavid M Ojcius
Jun 13, 2006·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Yoshinao AzumaMutsunori Shirai
Sep 16, 2006·Cellular & Molecular Biology Letters·Indrajit ChowdhuryGanapathy K Bhat
Dec 11, 2007·Microbes and Infection·Songmin YingGeorg Häcker
Jan 29, 2008·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Koshiro MiuraMutsunori Shirai
Feb 12, 2008·Vaccine·Christopher J BarkerPeter Timms
Aug 10, 2012·PLoS Pathogens·Allan L ChenMing Tan
Apr 23, 2013·Yeast·Tomoaki FukunagaRinji Akada
Jul 31, 2013·PloS One·Chunxue LuGuangming Zhong
Aug 21, 2015·Apoptosis : an International Journal on Programmed Cell Death·Mohd Akhlakur RahmanYoshinao Azuma
Mar 30, 2017·ELife·Annette FischerThomas Rudel