Identification of chromosome changes in acute myeloid leukemia (AML-M2) by molecular cytogenetics

Cancer Genetics and Cytogenetics
R L StarzaC Mecucci

Abstract

Karyotyping with fluorescence in situ hybridization (FISH) is reported in two rare cases of AML-M2 FAB. In the first case FISH analysis confirmed the presence of a t(7;11)(p15:p15) translocation in a complex karyotype that also showed an unbalanced translocation involving the other chromosome 7, a rare rearrangement between chromosomes 9 and 20, and four or five copies of a small marker derived from chromosome 9. In the second case whole chromosome painting with probes for chromosomes 8, 14, and 21 revealed the presence of a masked t(8;21) translocation in which one chromosome 14 was involved in a newly discovered rearrangement, i.e., t(8;14;21)(q22-q24;q11;q22). Moreover , double color FISH using ETO-CDR P1 probe and a cosmid for the 5' part of AML-1 on chromosome 21 showed a two color signal on the 8q-, suggesting a recombination between ETO and AML 1. Molecular cytogenetics overcomes limitation of chromosome banding in the interpretation of complex rearrangements.

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Citations

Jun 2, 2005·Leukemia Research·Francesco AlbanoMariano Rocchi
Jul 21, 1998·Leukemia Research·C Mecucci
Dec 23, 2010·Future Oncology·Etienne De BraekeleerMarc De Braekeleer
Jan 31, 2003·Genes, Chromosomes & Cancer·Ulrike GamerdingerJochen Harbott
Aug 22, 2006·International Journal of Cancer. Journal International Du Cancer·Kimberley HatfieldOystein Bruserud
Aug 5, 2014·American Journal of Hematology·Melhem SolhCelalettin Ustun
Feb 24, 2015·Genes, Chromosomes & Cancer·Joseph F CollinBarbara-Ann Guinn
Jun 6, 2020·Journal of Immunotherapy·Brigitte StegerHelga Maria Schmetzer
Apr 27, 2013·American Journal of Hematology·Roberto CairoliEnrica Morra
Jan 14, 1999·Genes, Chromosomes & Cancer·S TaviauxM Lafage-Pochitaloff

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