Identification of Chronic Obstructive Pulmonary Disease Axes That Predict All-Cause Mortality: The COPDGene Study

American Journal of Epidemiology
Gregory L KinneyCOPDGene Investigators

Abstract

Chronic obstructive pulmonary disease (COPD) is a syndrome caused by damage to the lungs that results in decreased pulmonary function and reduced structural integrity. Pulmonary function testing (PFT) is used to diagnose and stratify COPD into severity groups, and computed tomography (CT) imaging of the chest is often used to assess structural changes in the lungs. We hypothesized that the combination of PFT and CT phenotypes would provide a more powerful tool for assessing underlying morphologic differences associated with pulmonary function in COPD than does PFT alone. We used factor analysis of 26 variables to classify 8,157 participants recruited into the COPDGene cohort between January 2008 and June 2011 from 21 clinical centers across the United States. These factors were used as predictors of all-cause mortality using Cox proportional hazards modeling. Five factors explained 80% of the covariance and represented the following domains: factor 1, increased emphysema and decreased pulmonary function; factor 2, airway disease and decreased pulmonary function; factor 3, gas trapping; factor 4, CT variability; and factor 5, hyperinflation. After more than 46,079 person-years of follow-up, factors 1 through 4 were associated wi...Continue Reading

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Citations

Nov 21, 2019·American Journal of Respiratory and Critical Care Medicine·Alvar Agusti, Rosa Faner
Sep 22, 2020·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Kristian BratVladimir Koblizek
Nov 7, 2019·Therapeutic Advances in Respiratory Disease·Jose Luis Lopez-CamposJoan B Soriano
May 15, 2020·Nature·Amanda Keener
Aug 21, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·H Burke, T M A Wilkinson

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