Identification of cigarette smoke components that alter functioning of hamster (Mesocricetus auratus) oviducts in vitro

Biology of Reproduction
Prue TalbotC Gomez

Abstract

Previous studies have shown that solutions of mainstream and sidestream cigarette smoke decrease both ciliary beat frequency and oocyte cumulus complex pick-up rate of hamster oviducts in vitro. The purpose of this study was to identify the component(s) in smoke that produces these effects. Chemicals reported to be ciliotoxic in other systems were tested on hamster infundibula at various concentrations to determine whether a dose-response inhibition of ciliary beat frequency occurred. In addition, the concentration of each test component was measured in mainstream and sidestream smoke solutions (whole, particulate, and gas phase). All test components (acrolein, formaldehyde, phenol, acetaldehyde, and potassium cyanide [KCN]) inhibited ciliary beat frequency in a dose-dependent manner. Inhibition of ciliary beat frequency was at least partially reversible for all test compounds except acrolein. The concentrations of acrolein, formaldehyde, and phenol that were required to inhibit beat frequency were at least 3-50 times higher than their corresponding concentrations in smoke solutions. In contrast, cyanide was present in all smoke solutions at concentrations sufficient to inhibit ciliary beat frequency. Cilia on the outer surface...Continue Reading

Citations

Mar 19, 2003·Reproductive Toxicology·Karen RivelesP Talbot
Sep 21, 2000·Proceedings of the Society for Experimental Biology and Medicine·T A WyattJ H Sisson
Dec 17, 2010·International Journal of Environmental Health Research·Vitor E ValentiCelso Ferreira
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May 14, 2004·Reproductive Biology and Endocrinology : RB&E·Karen RivelesPrue Talbot
Sep 30, 2005·Reproductive Biology and Endocrinology : RB&E·Prue Talbot, Karen Riveles
Jan 1, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Vasundhra BahlPrue Talbot
Sep 21, 2011·Gynécologie, obstétrique & fertilité·C DechanetH Dechaud
Feb 18, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Karen RivelesP Talbot
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Feb 24, 2012·Biology of Reproduction·Ruijin ShaoHåkan Billig

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