Identification of circulating microRNA signatures for upper tract urothelial carcinoma detection

Molecular Medicine Reports
Jun TaoChangjun Yin

Abstract

The involvement of circulating microRNAs (miRNAs) in cancer and their potential as diagnostic and prognostic biomarkers are becoming increasingly known. However, the significance of circulating miRNAs in upper tract urothelial carcinoma (UTUC) has remained to be investigated. The present study performed a genome‑wide serum miRNA analysis using a deep sequencing platform for initial screening. Subsequently, serum samples of 46 UTUC patients and 30 cancer‑free individuals with hematuria were subjected to a quantitative reverse‑transcription polymerase chain reaction analysis. The expression of thirteen miRNAs (miR‑664a‑3p, miR‑423‑5p, miR‑431‑5p, miR‑191‑5p, miR‑92a‑3p, miR‑22‑3p, miR‑26a‑5p, miR‑33b‑3p, miR‑16‑5p, let‑7a‑5p, let‑7b‑5p, let‑7f‑5p and let‑7c) was significantly different in serum from UTUC patients compared with that in control samples. Receiver operator characteristic analysis showed that 10 miRNAs (miR‑664a‑3p, miR‑431‑5p, miR‑423‑5p, miR‑191‑5p, miR‑33b‑3p, miR‑26a‑5p, miR‑22‑3p, miR‑16‑5p, let‑7b‑5p and let‑7c) had the potential to distinguish individuals with UTUC from the controls (areas under the curve >0.8). The present study provided the first evidence for the potential use of circulating miRNAs as biomark...Continue Reading

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Citations

Sep 2, 2016·Current Opinion in Urology·Solene-Florence Kammerer-JacquetKarim Bensalah
Apr 21, 2017·Oncotarget·Xiaobing LiuLongkun Li
Aug 8, 2020·Journal of Clinical Laboratory Analysis·Jingyao WangYongqing Lai
Apr 24, 2018·Oncotarget·Ruth MontalboLourdes Mengual
Sep 10, 2019·Expert Review of Molecular Diagnostics·Philip ZeuschnerKerstin Junker
Jul 22, 2019·Molecular Diagnosis & Therapy·Qi LiJunling Shi
Apr 4, 2021·International Journal of Molecular Sciences·Przemysław A StemporPaula Dobosz
Nov 23, 2021·Frontiers in Oncology·Yu MeiHuanjie Yang

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Methods Mentioned

BETA
PCA

Software Mentioned

R
SPSS
DEGseq

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